PTH2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PTH2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTH2 at tissue level.

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0005576Cellular componentextracellular region

IV. Literature review

[source]
Gene namePTH2
Protein namePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Inositol polyphosphate 3-phosphatase) (Phosphatase and tensin homolog)
Tuberoinfundibular peptide of 39 residues (TIP39) (Parathyroid hormone 2)
SynonymsTIP39
TIPF39
DescriptionFUNCTION: Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action on PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. .

AccessionsQ96A98
ENST00000270631.2
O43460