PTDSS2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTDSS2 at tissue level.

III. Associated gene sets

GO_0006659Biological processphosphatidylserine biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016740Molecular functiontransferase activity
GO_0106245Molecular functionL-serine-phosphatidylethanolamine phosphatidyltransferase activity
GO_0003882Molecular functionCDP-diacylglycerol-serine O-phosphatidyltransferase activity

IV. Literature review

[source]
Gene namePTDSS2
Protein namePhosphatidylserine synthase 2
Phosphatidylserine synthase (EC 2.7.8.29) (Serine-exchange enzyme)
Phosphatidylserine synthase 2 (PSS-2) (PtdSer synthase 2) (EC 2.7.8.29) (Serine-exchange enzyme II)
SynonymsPSS2
DescriptionFUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine . Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine . Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity). .

FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine. .

AccessionsENST00000527479.5
A0A0J9YWQ2
ENST00000531520.5
Q9BVG9
E9PS47
E9PLE4
ENST00000308020.6
ENST00000633628.1