PRODH2 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell of proximal tubule	8 studies	40% ± 16%	Explore
hepatocyte	5 studies	33% ± 24%	Explore

Name	Number of supported studies	Average coverage
kidney	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	6517.62	226 / 226	89%	72.60	363 / 406
kidney	100%	8580.15	89 / 89	64%	18.00	573 / 901
pancreas	100%	216.81	328 / 328	1%	0.94	2 / 178
stomach	15%	1.99	53 / 359	2%	0.23	6 / 286
brain	12%	1.65	305 / 2642	0%	0	0 / 705
adipose	7%	2.65	89 / 1204	0%	0	0 / 0
peripheral blood	5%	2.36	50 / 929	0%	0	0 / 0
spleen	4%	6.65	9 / 241	0%	0	0 / 0
thymus	3%	0.65	21 / 653	0%	0	0 / 605
intestine	3%	0.50	25 / 966	1%	0.10	3 / 527
breast	2%	0.70	11 / 459	0%	0.04	2 / 1118
esophagus	1%	0.29	16 / 1445	1%	0.09	2 / 183
prostate	2%	0.19	4 / 245	0%	0	0 / 502
uterus	1%	0.15	2 / 170	0%	0.04	2 / 459
adrenal gland	1%	0.19	2 / 258	0%	0.15	1 / 230
skin	1%	0.25	19 / 1809	0%	0	0 / 472
blood vessel	1%	0.24	13 / 1335	0%	0	0 / 0
lung	1%	0.07	3 / 578	0%	0.11	4 / 1155
heart	1%	0.18	5 / 861	0%	0	0 / 0
muscle	0%	0.04	3 / 803	0%	0	0 / 0
ovary	0%	0	0 / 180	0%	0.01	1 / 430
abdomen	0%	0	0 / 0	0%	0	0 / 0
bladder	0%	0	0 / 21	0%	0	0 / 504
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0010133	Biological process	proline catabolic process to glutamate
GO_0006562	Biological process	proline catabolic process
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0071949	Molecular function	FAD binding
GO_0004657	Molecular function	proline dehydrogenase activity
GO_0016645	Molecular function	oxidoreductase activity, acting on the CH-NH group of donors

Gene name	PRODH2
Protein name	Hydroxyproline dehydrogenase (HYPDH) (EC 1.5.5.3) (Kidney and liver proline oxidase 1) (HsPOX1) (Probable proline dehydrogenase 2) (EC 1.5.5.2) (Probable proline oxidase 2) Proline dehydrogenase (EC 1.5.5.2)
Synonyms	HYPDH HSPOX1
Description	FUNCTION: Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis. . FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate. . FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate. .
Accessions	ENST00000588266.6 ENST00000589835.1 Q9UF12 K7EJK5 ENST00000653904.2 S4R3D8 ENST00000301175.7

PRODH2 report