PPT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PPT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PPT2 at tissue level.

III. Associated gene sets

GO_0098734Biological processmacromolecule depalmitoylation
GO_0046949Biological processfatty-acyl-CoA biosynthetic process
GO_0005764Cellular componentlysosome
GO_0043202Cellular componentlysosomal lumen
GO_0070062Cellular componentextracellular exosome
GO_0016790Molecular functionthiolester hydrolase activity
GO_0098599Molecular functionpalmitoyl hydrolase activity

IV. Literature review

[source]
Gene namePPT2
Protein namePPT2
Lysosomal thioesterase PPT2
PPT2-EGFL8 readthrough (NMD candidate) (Palmitoyl-protein thioesterase 2)
Palmitoyl-protein thioesterase 2
Lysosomal thioesterase PPT2 (PPT-2) (EC 3.1.2.-) (S-thioesterase G14)
SynonymsPPT2-EGFL8
DescriptionFUNCTION: Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins. .

AccessionsQ9UMR5
ENST00000424667.5
ENST00000399665.5
ENST00000441396.1
ENST00000483565.5
ENST00000416489.5
ENST00000375143.6 [Q9UMR5-1]
ENST00000324816.11 [Q9UMR5-1]
ENST00000547309.2
ENST00000453393.1
ENST00000480383.5
ENST00000469411.5
ENST00000492976.5
ENST00000425475.5
ENST00000424353.5
ENST00000415972.1
ENST00000585246.5
ENST00000438385.6
ENST00000469283.1
ENST00000437214.5
ENST00000550796.2
ENST00000458119.5
ENST00000478621.5
ENST00000414356.6
ENST00000431338.5
ENST00000458042.5
ENST00000460446.1
A0A0G2JHB6
ENST00000456497.5
ENST00000583227.5
ENST00000476214.5
A0A0G2JHI0
ENST00000451460.5
ENST00000383301.6
A0A0G2JIU6
ENST00000457509.5
ENST00000414204.5
ENST00000436118.2
ENST00000413836.1
A0A0G2JK07
A0A0G2JK02
A2ABN6
ENST00000488579.5
ENST00000399856.5
A0A140TA16
ENST00000551222.2
ENST00000546871.2
ENST00000399660.5
ENST00000496937.5
ENST00000443298.5
ENST00000419970.5
ENST00000425659.5
ENST00000416892.5
A0A140T8X7
ENST00000399662.5
ENST00000527704.5
ENST00000431414.5
ENST00000486292.1
ENST00000420778.5
ENST00000440533.5
ENST00000427642.5
ENST00000497702.5
ENST00000493809.5
ENST00000423347.6
ENST00000452304.5
ENST00000525601.5
G8JLL2
ENST00000412651.6
ENST00000446563.5
ENST00000494953.5
A0A0G2JI52
A0A0G2JKR3
A0A140T9Y1
ENST00000433658.5
ENST00000475020.1
ENST00000445462.5
ENST00000493225.5
A0A0G2JLK6
ENST00000483803.5
A0A0G2JLK3
ENST00000422988.6
ENST00000458738.1
A0A024RCX6
A0A0G2JID8
ENST00000490624.5
ENST00000427896.5
ENST00000443321.5
ENST00000424311.1
A0A0G2JH76
ENST00000429189.5
ENST00000442463.5
ENST00000452562.5
ENST00000433748.5
ENST00000375137.6 [Q9UMR5-1]
ENST00000383152.6
ENST00000552922.2
ENST00000447703.5
ENST00000427556.5
ENST00000426325.5
ENST00000361568.6 [Q9UMR5-3]
ENST00000488435.5
A0A0G2JLK8
ENST00000424499.1
ENST00000395523.5 [Q9UMR5-1]
ENST00000399859.5
A2ABN7
ENST00000399860.5
ENST00000440507.5
ENST00000547646.2
ENST00000467040.5
ENST00000429696.6
ENST00000485053.5
A0A0G2JLK9
ENST00000418283.5
ENST00000426390.1