I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 25% ± 7% | |
| glutamatergic neuron | 4 studies | 38% ± 10% | |
| GABAergic neuron | 3 studies | 28% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 5 studies | 25% ± 7% | |
| glutamatergic neuron | 4 studies | 38% ± 10% | |
| GABAergic neuron | 3 studies | 28% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 436.51 | 1445 / 1445 | 100% | 16.10 | 183 / 183 |
| ovary | 100% | 842.09 | 180 / 180 | 100% | 13.45 | 430 / 430 |
| brain | 100% | 619.72 | 2639 / 2642 | 100% | 13.16 | 705 / 705 |
| breast | 100% | 484.44 | 459 / 459 | 100% | 16.92 | 1114 / 1118 |
| stomach | 100% | 375.87 | 359 / 359 | 99% | 13.96 | 282 / 286 |
| uterus | 100% | 545.96 | 170 / 170 | 98% | 13.59 | 449 / 459 |
| intestine | 100% | 451.68 | 965 / 966 | 98% | 14.61 | 516 / 527 |
| lung | 98% | 334.69 | 568 / 578 | 99% | 14.41 | 1148 / 1155 |
| prostate | 100% | 460.98 | 245 / 245 | 97% | 10.44 | 488 / 502 |
| bladder | 100% | 490.29 | 21 / 21 | 97% | 12.12 | 488 / 504 |
| pancreas | 100% | 496.71 | 328 / 328 | 96% | 7.25 | 170 / 178 |
| skin | 100% | 854.31 | 1806 / 1809 | 95% | 16.06 | 450 / 472 |
| thymus | 100% | 517.44 | 653 / 653 | 92% | 6.18 | 555 / 605 |
| adrenal gland | 100% | 752.26 | 258 / 258 | 88% | 7.20 | 202 / 230 |
| kidney | 100% | 457.84 | 89 / 89 | 84% | 6.60 | 755 / 901 |
| liver | 100% | 392.95 | 226 / 226 | 68% | 4.38 | 278 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.06 | 29 / 29 |
| spleen | 100% | 481.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.46 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.91 | 1 / 1 |
| adipose | 100% | 445.15 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 374.06 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 305.24 | 795 / 803 | 0% | 0 | 0 / 0 |
| heart | 91% | 219.43 | 784 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 63% | 4.37 | 50 / 80 |
| peripheral blood | 46% | 836.94 | 429 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0044208 | Biological process | 'de novo' AMP biosynthetic process |
| GO_0006164 | Biological process | purine nucleotide biosynthetic process |
| GO_0006541 | Biological process | glutamine metabolic process |
| GO_0006189 | Biological process | 'de novo' IMP biosynthetic process |
| GO_0006177 | Biological process | GMP biosynthetic process |
| GO_0097294 | Biological process | 'de novo' XMP biosynthetic process |
| GO_0009113 | Biological process | purine nucleobase biosynthetic process |
| GO_0005829 | Cellular component | cytosol |
| GO_0004044 | Molecular function | amidophosphoribosyltransferase activity |
| GO_0051539 | Molecular function | 4 iron, 4 sulfur cluster binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PPAT |
| Protein name | Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT) Phosphoribosyl pyrophosphate amidotransferase |
| Synonyms | GPAT hCG_2027246 |
| Description | FUNCTION: Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. . |
| Accessions | D6RCC8 A8K4H7 ENST00000507724.1 ENST00000264220.6 Q06203 ENST00000510643.5 D6RE15 |
