PON1 | OmnibusX

Name	Number of supported studies	Average coverage
hepatocyte	5 studies	54% ± 15%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PON1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	13840.52	226 / 226	95%	268.24	387 / 406
brain	97%	52.56	2564 / 2642	43%	1.19	300 / 705
ovary	100%	121.30	180 / 180	36%	2.80	156 / 430
adrenal gland	97%	866.33	249 / 258	38%	11.19	88 / 230
lung	90%	35.64	523 / 578	27%	1.22	312 / 1155
pancreas	70%	14.71	230 / 328	21%	1.30	38 / 178
prostate	69%	33.72	169 / 245	22%	4.03	112 / 502
breast	78%	28.72	358 / 459	13%	0.61	148 / 1118
skin	68%	20.87	1224 / 1809	1%	0.05	7 / 472
intestine	53%	8.71	511 / 966	12%	1.00	61 / 527
adipose	64%	15.33	770 / 1204	0%	0	0 / 0
heart	59%	10.69	508 / 861	0%	0	0 / 0
kidney	56%	10.46	50 / 89	2%	1.07	22 / 901
uterus	49%	8.49	83 / 170	9%	0.33	40 / 459
stomach	43%	5.71	154 / 359	9%	0.57	26 / 286
thymus	41%	7.42	267 / 653	11%	1.92	67 / 605
bladder	43%	9.10	9 / 21	8%	0.71	40 / 504
esophagus	21%	2.89	308 / 1445	15%	0.41	27 / 183
spleen	18%	21.45	44 / 241	0%	0	0 / 0
peripheral blood	18%	17.23	163 / 929	0%	0	0 / 0
muscle	16%	2.15	131 / 803	0%	0	0 / 0
blood vessel	14%	2.51	185 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.09	1 / 45
eye	0%	0	0 / 0	1%	0.06	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0034445	Biological process	negative regulation of plasma lipoprotein oxidation
GO_1901335	Biological process	lactone catabolic process
GO_0008203	Biological process	cholesterol metabolic process
GO_0046395	Biological process	carboxylic acid catabolic process
GO_0010875	Biological process	positive regulation of cholesterol efflux
GO_0046470	Biological process	phosphatidylcholine metabolic process
GO_0009636	Biological process	response to toxic substance
GO_0046434	Biological process	organophosphate catabolic process
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0034366	Cellular component	spherical high-density lipoprotein particle
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0070062	Cellular component	extracellular exosome
GO_0034364	Cellular component	high-density lipoprotein particle
GO_0072562	Cellular component	blood microparticle
GO_0042803	Molecular function	protein homodimerization activity
GO_0005543	Molecular function	phospholipid binding
GO_0004063	Molecular function	aryldialkylphosphatase activity
GO_0102007	Molecular function	acyl-L-homoserine-lactone lactonohydrolase activity
GO_0004064	Molecular function	arylesterase activity
GO_0005509	Molecular function	calcium ion binding

Gene name	PON1
Protein name	Paraoxonase Paraoxonase (EC 3.1.1.2) Paraoxonase 1 Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1)
Synonyms	PON
Description	FUNCTION: Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation. .
Accessions	P27169 Q96P89 ENST00000222381.8 ENST00000433729.1 F8WF42 Q96P90 Q96P91 A0A7G4RBS0 A0A7G4RBR1 A0A7G4RBQ1

PON1 report