POLR2M report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POLR2M at tissue level.

III. Associated gene sets

GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0035556Biological processintracellular signal transduction
GO_0051685Biological processmaintenance of ER location
GO_0097550Cellular componenttranscription preinitiation complex
GO_0016591Cellular componentRNA polymerase II, holoenzyme
GO_0031674Cellular componentI band
GO_0005665Cellular componentRNA polymerase II, core complex
GO_0005622Cellular componentintracellular anatomical structure
GO_0043025Cellular componentneuronal cell body
GO_0005635Cellular componentnuclear envelope
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0003711Molecular functiontranscription elongation factor activity

IV. Literature review

[source]
Gene namePOLR2M
Protein nameDNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 (DNA-directed RNA polymerase II subunit M, isoforms 4/5)
DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A)
RNA polymerase II subunit M
SynonymsGRINL1A
DescriptionFUNCTION: [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. .

AccessionsENST00000482852.5 [P0CAP2-3]
P0CAP2
ENST00000380557.4 [P0CAP2-2]
ENST00000299638.8 [P0CAP2-1]
ENST00000464277.2
ENST00000494490.2
E9PP13
Q6EEV4
ENST00000649091.1 [Q6EEV4-2]