POGLUT2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POGLUT2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POGLUT2 at tissue level.

III. Associated gene sets

GO_0018242Biological processprotein O-linked glycosylation via serine
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0012505Cellular componentendomembrane system
GO_0046527Molecular functionglucosyltransferase activity
GO_0140562Molecular functionEGF-domain serine xylosyltransferase activity
GO_0035251Molecular functionUDP-glucosyltransferase activity
GO_0035252Molecular functionUDP-xylosyltransferase activity
GO_0140561Molecular functionEGF-domain serine glucosyltransferase activity

IV. Literature review

[source]
Gene namePOGLUT2
Protein nameProtein O-glucosyltransferase 2
Alternative protein KDELC1
Protein O-glucosyltransferase 2 (EC 2.4.1.-) (Endoplasmic reticulum resident protein 58) (ER protein 58) (ERp58) (KDEL motif-containing protein 1) (Protein O-xylosyltransferase POGLUT2) (EC 2.4.2.-)
SynonymsUNQ1910/PRO4357
KDELC1
EP58
DescriptionFUNCTION: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C . Can also catalyze the transfer of xylose from UDP-xylose but less efficiently . Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 . May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway . .

AccessionsENST00000706520.1
Q6UW63
ENST00000706519.1
A0A9L9PX85
L8EAD3
ENST00000376004.5
A0A9L9PXM5
ENST00000706521.1
ENST00000706516.1
A0A9L9PXK3
A0A9L9PY35