I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 36% ± 6% | |
| ciliated cell | 3 studies | 32% ± 6% | |
| dendritic cell | 3 studies | 41% ± 36% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 3 studies | 36% ± 6% | |
| ciliated cell | 3 studies | 32% ± 6% | |
| dendritic cell | 3 studies | 41% ± 36% |
Insufficient scRNA-seq data for expression of PNPLA4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 1023.64 | 653 / 653 | 100% | 29.92 | 604 / 605 |
| prostate | 100% | 652.15 | 245 / 245 | 100% | 26.91 | 501 / 502 |
| pancreas | 100% | 605.15 | 327 / 328 | 100% | 14.48 | 178 / 178 |
| kidney | 100% | 1278.51 | 89 / 89 | 99% | 24.93 | 895 / 901 |
| adrenal gland | 100% | 1480.12 | 258 / 258 | 99% | 25.94 | 228 / 230 |
| ovary | 100% | 1083.56 | 180 / 180 | 99% | 24.03 | 424 / 430 |
| skin | 100% | 815.43 | 1808 / 1809 | 98% | 19.56 | 464 / 472 |
| liver | 100% | 817.17 | 226 / 226 | 98% | 16.33 | 398 / 406 |
| breast | 100% | 794.02 | 459 / 459 | 98% | 33.79 | 1095 / 1118 |
| uterus | 100% | 672.25 | 170 / 170 | 96% | 21.67 | 441 / 459 |
| intestine | 99% | 531.80 | 957 / 966 | 96% | 20.43 | 507 / 527 |
| bladder | 100% | 467.71 | 21 / 21 | 94% | 16.06 | 474 / 504 |
| stomach | 100% | 800.46 | 358 / 359 | 93% | 18.71 | 267 / 286 |
| esophagus | 100% | 692.54 | 1442 / 1445 | 92% | 11.22 | 168 / 183 |
| lung | 91% | 443.49 | 526 / 578 | 98% | 18.43 | 1127 / 1155 |
| brain | 100% | 1001.15 | 2640 / 2642 | 69% | 9.97 | 483 / 705 |
| eye | 0% | 0 | 0 / 0 | 100% | 24.71 | 80 / 80 |
| muscle | 100% | 1390.27 | 803 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 16.30 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.70 | 1 / 1 |
| adipose | 100% | 662.81 | 1202 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 399.63 | 240 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 491.85 | 1322 / 1335 | 0% | 0 | 0 / 0 |
| heart | 96% | 1037.64 | 827 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 11.56 | 27 / 29 |
| peripheral blood | 50% | 208.07 | 467 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019433 | Biological process | triglyceride catabolic process |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0008150 | Biological process | biological_process |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0016020 | Cellular component | membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0047376 | Molecular function | all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity |
| GO_0004806 | Molecular function | triglyceride lipase activity |
| GO_0004623 | Molecular function | phospholipase A2 activity |
| GO_0051264 | Molecular function | mono-olein transacylation activity |
| GO_0051265 | Molecular function | diolein transacylation activity |
| GO_0050253 | Molecular function | retinyl-palmitate esterase activity |
| GO_0016411 | Molecular function | acylglycerol O-acyltransferase activity |
| Gene name | PNPLA4 |
| Protein name | Patatin-like phospholipase domain-containing protein 4 (EC 3.1.1.3) (Calcium-independent phospholipase A2-eta) (iPLA2-eta) (EC 3.1.1.4) (Protein GS2) Patatin like phospholipase domain containing 4 |
| Synonyms | GS2 DXS1283E |
| Description | FUNCTION: Has abundant triacylglycerol lipase activity . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides . Additionally possesses acylglycerol transacylase and phospholipase A2 activities . . |
| Accessions | ENST00000537427.5 [P41247-2] ENST00000444736.5 [P41247-1] C9IZF6 ENST00000381042.9 [P41247-1] ENST00000442940.1 P41247 |
