I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| adipocyte | 7 studies | 34% ± 11% | |
| retinal pigment epithelial cell | 4 studies | 47% ± 19% | |
| hepatocyte | 3 studies | 55% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 7 studies | 34% ± 11% | |
| retinal pigment epithelial cell | 4 studies | 47% ± 19% | |
| hepatocyte | 3 studies | 55% ± 15% |
Insufficient scRNA-seq data for expression of PNPLA3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 100% | 2294.74 | 226 / 226 | 96% | 14.26 | 388 / 406 |
| skin | 98% | 731.21 | 1777 / 1809 | 78% | 5.62 | 367 / 472 |
| breast | 71% | 259.85 | 325 / 459 | 47% | 2.89 | 525 / 1118 |
| lung | 63% | 96.93 | 362 / 578 | 49% | 1.85 | 561 / 1155 |
| kidney | 66% | 132.89 | 59 / 89 | 32% | 0.76 | 289 / 901 |
| ovary | 33% | 35.07 | 60 / 180 | 56% | 1.67 | 241 / 430 |
| brain | 25% | 25.45 | 655 / 2642 | 55% | 1.73 | 389 / 705 |
| adipose | 75% | 345.83 | 909 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 1% | 1.30 | 2 / 328 | 67% | 1.94 | 119 / 178 |
| uterus | 11% | 15.42 | 19 / 170 | 53% | 1.76 | 241 / 459 |
| esophagus | 11% | 10.90 | 152 / 1445 | 52% | 1.91 | 95 / 183 |
| muscle | 57% | 171.17 | 461 / 803 | 0% | 0 | 0 / 0 |
| intestine | 11% | 15.52 | 108 / 966 | 39% | 1.63 | 208 / 527 |
| eye | 0% | 0 | 0 / 0 | 50% | 1.16 | 40 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 42% | 1.14 | 19 / 45 |
| stomach | 12% | 13.00 | 42 / 359 | 29% | 1.22 | 82 / 286 |
| spleen | 36% | 34.40 | 87 / 241 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 25% | 0.89 | 125 / 504 |
| adrenal gland | 17% | 20.41 | 44 / 258 | 6% | 0.14 | 14 / 230 |
| blood vessel | 7% | 22.65 | 100 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 4% | 5.69 | 25 / 653 | 3% | 0.09 | 21 / 605 |
| heart | 4% | 6.63 | 33 / 861 | 0% | 0 | 0 / 0 |
| prostate | 2% | 2.05 | 6 / 245 | 0% | 0.01 | 2 / 502 |
| peripheral blood | 2% | 1.85 | 16 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0036155 | Biological process | acylglycerol acyl-chain remodeling |
| GO_0006650 | Biological process | glycerophospholipid metabolic process |
| GO_0032869 | Biological process | cellular response to insulin stimulus |
| GO_0036153 | Biological process | triglyceride acyl-chain remodeling |
| GO_0019433 | Biological process | triglyceride catabolic process |
| GO_0019432 | Biological process | triglyceride biosynthetic process |
| GO_0009744 | Biological process | response to sucrose |
| GO_0034389 | Biological process | lipid droplet organization |
| GO_0001676 | Biological process | long-chain fatty acid metabolic process |
| GO_0006654 | Biological process | phosphatidic acid biosynthetic process |
| GO_1905243 | Biological process | cellular response to 3,3',5-triiodo-L-thyronine |
| GO_0055088 | Biological process | lipid homeostasis |
| GO_0050872 | Biological process | white fat cell differentiation |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0051264 | Molecular function | mono-olein transacylation activity |
| GO_0003841 | Molecular function | 1-acylglycerol-3-phosphate O-acyltransferase activity |
| GO_0004465 | Molecular function | lipoprotein lipase activity |
| GO_0004806 | Molecular function | triglyceride lipase activity |
| GO_0004623 | Molecular function | phospholipase A2 activity |
| GO_0016411 | Molecular function | acylglycerol O-acyltransferase activity |
| GO_0051265 | Molecular function | diolein transacylation activity |
| GO_0036042 | Molecular function | long-chain fatty acyl-CoA binding |
| GO_0042171 | Molecular function | lysophosphatidic acid acyltransferase activity |
| GO_0035727 | Molecular function | lysophosphatidic acid binding |
| Gene name | PNPLA3 |
| Protein name | Patatin like phospholipase domain containing 3 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (EC 2.3.1.51) (Acylglycerol transacylase) (Adiponutrin) (ADPN) (Calcium-independent phospholipase A2-epsilon) (iPLA2-epsilon) (EC 3.1.1.4) (Lysophosphatidic acid acyltransferase) (Patatin-like phospholipase domain-containing protein 3) (EC 3.1.1.3) Patatin-like phospholipase domain-containing protein 3 |
| Synonyms | ADPN C22orf20 |
| Description | FUNCTION: Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA . Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides . In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety . However, the triacylglycerol hydrolase activity is controversial and may be very low . Possesses phospholipase A2 activity . . |
| Accessions | ENST00000216180.8 [Q9NST1-1] ENST00000406117.6 F8W8E5 U3N901 U3N4F2 Q9NST1 ENST00000423180.2 [Q9NST1-2] |
