PNLIPRP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PNLIPRP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PNLIPRP2 at tissue level.

III. Associated gene sets

GO_0019433Biological processtriglyceride catabolic process
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0006641Biological processtriglyceride metabolic process
GO_0019376Biological processgalactolipid catabolic process
GO_0044241Biological processlipid digestion
GO_0009395Biological processphospholipid catabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0042589Cellular componentzymogen granule membrane
GO_0043005Cellular componentneuron projection
GO_0004806Molecular functiontriglyceride lipase activity
GO_0004620Molecular functionphospholipase activity
GO_0047714Molecular functiongalactolipase activity
GO_0047372Molecular functionacylglycerol lipase activity
GO_0102549Molecular function1-18:1-2-16:0-monogalactosyldiacylglycerol lipase activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene namePNLIPRP2
Protein namePancreatic lipase-related protein 2 (PL-RP2) (Cytotoxic T lymphocyte lipase) (Galactolipase) (EC 3.1.1.26) (Triacylglycerol lipase) (EC 3.1.1.3)
SynonymsPLRP2
DescriptionFUNCTION: Lipase that primarily hydrolyzes triglycerides and galactosylglycerides . In neonates, may play a major role in pancreatic digestion of dietary fats such as milk fat globules enriched in long-chain triglycerides . Hydrolyzes short-, medium- and long-chain fatty acyls in triglycerides without apparent positional specificity . Can completely deacylate triacylglycerols . When the liver matures and bile salt synthesis increases, likely functions mainly as a galactolipase and monoacylglycerol lipase. Hydrolyzes monogalactosyldiglycerols (MGDG) and digalactosyldiacylglycerols (DGDG) present in a plant-based diet, releasing long-chain polyunsaturated fatty acids . Hydrolyzes medium- and long-chain fatty acyls in galactolipids . May act together with LIPF to hydrolyze partially digested triglycerides . Hydrolyzes long-chain monoglycerides with high efficiency . In cytotoxic T cells, contributes to perforin-dependent cell lysis, but is unlikely to mediate direct cytotoxicity (By similarity). Also has low phospholipase activity . In neurons, required for the localization of the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) to neurite tips through acyl chain remodeling of membrane phospholipids (By similarity). The resulting OPPC-rich lipid membrane domain recruits the t-SNARE protein STX4 by selectively interacting with the STX4 transmembrane domain and this promotes surface expression of the dopamine transporter SLC6A3/DAT at neurite tips by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity). .

AccessionsP54317