PM20D1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PM20D1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PM20D1 at tissue level.

III. Associated gene sets

GO_0044255Biological processcellular lipid metabolic process
GO_0097009Biological processenergy homeostasis
GO_0006520Biological processamino acid metabolic process
GO_0043605Biological processamide catabolic process
GO_0006508Biological processproteolysis
GO_0006631Biological processfatty acid metabolic process
GO_1990845Biological processadaptive thermogenesis
GO_0043604Biological processamide biosynthetic process
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0016811Molecular functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO_0008233Molecular functionpeptidase activity
GO_0016829Molecular functionlyase activity
GO_0004046Molecular functionaminoacylase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePM20D1
Protein nameN-fatty-acyl-amino acid synthase/hydrolase PM20D1 (EC 3.5.1.114) (EC 3.5.1.14) (Peptidase M20 domain-containing protein 1)
Synonyms
DescriptionFUNCTION: Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase . It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction . Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity). .

AccessionsQ6GTS8
ENST00000367136.5 [Q6GTS8-1]