PLXNA4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	11 studies	59% ± 22%	Explore
GABAergic neuron	10 studies	49% ± 22%	Explore
adipocyte	10 studies	57% ± 18%	Explore
oligodendrocyte precursor cell	8 studies	25% ± 6%	Explore
interneuron	6 studies	49% ± 18%	Explore
neuron	5 studies	32% ± 9%	Explore
astrocyte	4 studies	36% ± 23%	Explore
plasmacytoid dendritic cell	4 studies	18% ± 4%	Explore
cardiac muscle cell	4 studies	26% ± 5%	Explore
endothelial cell	3 studies	42% ± 18%	Explore
GABAergic interneuron	3 studies	56% ± 4%	Explore
progenitor cell	3 studies	28% ± 15%	Explore
endocardial cell	3 studies	27% ± 9%	Explore
mesothelial cell	3 studies	22% ± 5%	Explore
OFF-bipolar cell	3 studies	49% ± 27%	Explore
retinal cone cell	3 studies	18% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	12 studies	41% ± 21%	Explore
adipose	3 studies	22% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	88%	2398.99	2337 / 2642	99%	13.85	698 / 705
breast	96%	4809.89	442 / 459	62%	2.13	697 / 1118
ovary	97%	2131.92	175 / 180	51%	3.66	218 / 430
lung	77%	732.74	447 / 578	37%	1.00	428 / 1155
esophagus	74%	847.09	1072 / 1445	33%	0.87	60 / 183
thymus	31%	255.97	202 / 653	74%	4.96	445 / 605
skin	79%	1129.22	1432 / 1809	23%	0.98	109 / 472
uterus	78%	938.72	133 / 170	24%	2.71	110 / 459
adipose	100%	6364.31	1201 / 1204	0%	0	0 / 0
adrenal gland	35%	365.68	90 / 258	60%	6.95	139 / 230
spleen	95%	941.62	228 / 241	0%	0	0 / 0
intestine	65%	647.91	631 / 966	28%	0.66	150 / 527
blood vessel	89%	2002.06	1187 / 1335	0%	0	0 / 0
heart	89%	1434.39	765 / 861	0%	0	0 / 0
bladder	71%	585.67	15 / 21	14%	0.33	71 / 504
stomach	41%	790.06	147 / 359	38%	2.31	110 / 286
prostate	30%	244.26	73 / 245	20%	0.33	101 / 502
pancreas	6%	32.69	21 / 328	38%	1.02	68 / 178
kidney	22%	212.76	20 / 89	10%	0.38	90 / 901
muscle	20%	158.74	158 / 803	0%	0	0 / 0
liver	4%	20.12	8 / 226	6%	0.33	23 / 406
eye	0%	0	0 / 0	9%	0.12	7 / 80
lymph node	0%	0	0 / 0	7%	0.07	2 / 29
tonsil	0%	0	0 / 0	7%	0.20	3 / 45
peripheral blood	1%	5.99	11 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0050923	Biological process	regulation of negative chemotaxis
GO_0099558	Biological process	maintenance of synapse structure
GO_0050772	Biological process	positive regulation of axonogenesis
GO_0048485	Biological process	sympathetic nervous system development
GO_0021644	Biological process	vagus nerve morphogenesis
GO_0007162	Biological process	negative regulation of cell adhesion
GO_0021612	Biological process	facial nerve structural organization
GO_0021784	Biological process	postganglionic parasympathetic fiber development
GO_0021615	Biological process	glossopharyngeal nerve morphogenesis
GO_0048841	Biological process	regulation of axon extension involved in axon guidance
GO_0021793	Biological process	chemorepulsion of branchiomotor axon
GO_0021637	Biological process	trigeminal nerve structural organization
GO_0097492	Biological process	sympathetic neuron axon guidance
GO_0021785	Biological process	branchiomotor neuron axon guidance
GO_0021960	Biological process	anterior commissure morphogenesis
GO_0043087	Biological process	regulation of GTPase activity
GO_0030334	Biological process	regulation of cell migration
GO_0035050	Biological process	embryonic heart tube development
GO_0008045	Biological process	motor neuron axon guidance
GO_0008360	Biological process	regulation of cell shape
GO_0071526	Biological process	semaphorin-plexin signaling pathway
GO_0002116	Cellular component	semaphorin receptor complex
GO_0005886	Cellular component	plasma membrane
GO_0150053	Cellular component	cerebellar climbing fiber to Purkinje cell synapse
GO_0017154	Molecular function	semaphorin receptor activity

IV. Literature review

[source]

Gene name	PLXNA4
Protein name	Plexin A4 Plexin-A4
Synonyms	PLXNA4B KIAA1550 PLXNA4A UNQ2820/PRO34003 tcag7.1291
Description	FUNCTION: Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). .
Accessions	ENST00000359827.7 [Q9HCM2-1] ENST00000423507.6 [Q9HCM2-2] ENST00000378539.5 [Q9HCM2-3] A4D1N7 ENST00000321063.9 [Q9HCM2-1] Q9HCM2

PLXNA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review