PLXNA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021628Biological processolfactory nerve formation
GO_0008360Biological processregulation of cell shape
GO_1990138Biological processneuron projection extension
GO_0007162Biological processnegative regulation of cell adhesion
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0043087Biological processregulation of GTPase activity
GO_0030334Biological processregulation of cell migration
GO_0050772Biological processpositive regulation of axonogenesis
GO_0060666Biological processdichotomous subdivision of terminal units involved in salivary gland branching
GO_0021828Biological processgonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO_0014910Biological processregulation of smooth muscle cell migration
GO_0097485Biological processneuron projection guidance
GO_0070062Cellular componentextracellular exosome
GO_0002116Cellular componentsemaphorin receptor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0017154Molecular functionsemaphorin receptor activity

IV. Literature review

[source]
Gene namePLXNA1
Protein namePlexin A1
Plexin-A1 (Semaphorin receptor NOV)
SynonymsPLXN1
NOV
DescriptionFUNCTION: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). .

AccessionsA0A804HKL4
Q9UIW2
ENST00000393409.3
ENST00000684469.1