PLTP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015914Biological processphospholipid transport
GO_0046836Biological processglycolipid transport
GO_0015918Biological processsterol transport
GO_0120009Biological processintermembrane lipid transfer
GO_0035627Biological processceramide transport
GO_0034375Biological processhigh-density lipoprotein particle remodeling
GO_0006869Biological processlipid transport
GO_0010189Biological processvitamin E biosynthetic process
GO_0030317Biological processflagellated sperm motility
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0006629Biological processlipid metabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0034364Cellular componenthigh-density lipoprotein particle
GO_0005634Cellular componentnucleus
GO_0120017Molecular functionceramide transfer activity
GO_0140337Molecular functiondiacylglyceride transfer activity
GO_0097001Molecular functionceramide binding
GO_1901611Molecular functionphosphatidylglycerol binding
GO_0140339Molecular functionphosphatidylglycerol transfer activity
GO_0120020Molecular functioncholesterol transfer activity
GO_0008526Molecular functionphosphatidylinositol transfer activity
GO_0140338Molecular functionsphingomyelin transfer activity
GO_0140340Molecular functioncerebroside transfer activity
GO_0120014Molecular functionphospholipid transfer activity
GO_0031210Molecular functionphosphatidylcholine binding
GO_0030169Molecular functionlow-density lipoprotein particle binding
GO_0120019Molecular functionphosphatidylcholine transfer activity
GO_0070300Molecular functionphosphatidic acid binding
GO_1990050Molecular functionphosphatidic acid transfer activity
GO_0008429Molecular functionphosphatidylethanolamine binding
GO_0008035Molecular functionhigh-density lipoprotein particle binding
GO_0034189Molecular functionvery-low-density lipoprotein particle binding
GO_1904121Molecular functionphosphatidylethanolamine transfer activity
GO_0019992Molecular functiondiacylglycerol binding

IV. Literature review

[source]
Gene namePLTP
Protein namePhospholipid transfer protein, isoform CRA_c (cDNA FLJ39690 fis, clone SMINT2010639, highly similar to PHOSPHOLIPID TRANSFER PROTEIN)
Phospholipid transfer protein (Lipid transfer protein II)
SynonymshCG_37180
DescriptionFUNCTION: Mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves . Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine . Plays an important role in HDL remodeling which involves modulating the size and composition of HDL . Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion . Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability . .

AccessionsENST00000420868.2 [P55058-3]
ENST00000372420.5 [P55058-4]
ENST00000477313.5 [P55058-1]
ENST00000372431.8 [P55058-1]
B3KUE5
P55058
ENST00000354050.8 [P55058-2]