PLEKHA8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0120009Biological processintermembrane lipid transfer
GO_0015031Biological processprotein transport
GO_1902389Biological processceramide 1-phosphate transport
GO_0035621Biological processER to Golgi ceramide transport
GO_0035627Biological processceramide transport
GO_0046836Biological processglycolipid transport
GO_0006869Biological processlipid transport
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_1902388Molecular functionceramide 1-phosphate transfer activity
GO_0017089Molecular functionglycolipid transfer activity
GO_0097001Molecular functionceramide binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_1902387Molecular functionceramide 1-phosphate binding
GO_0051861Molecular functionglycolipid binding

IV. Literature review

[source]
Gene namePLEKHA8
Protein namePleckstrin homology domain containing A8
Pleckstrin homology domain-containing family A member 8 (Phosphatidylinositol-four-phosphate adapter protein 2)
Pleckstrin homology domain-containing family A member 8 (PH domain-containing family A member 8) (Phosphatidylinositol-four-phosphate adapter protein 2) (FAPP-2) (Phosphoinositol 4-phosphate adapter protein 2) (hFAPP2) (Serologically defined breast cancer antigen NY-BR-86)
SynonymsFAPP2
DescriptionFUNCTION: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation. .

AccessionsENST00000649443.1
Q96JA3
A0A2P1JJM6
ENST00000449726.6 [Q96JA3-1]
A0A3B3IST3
ENST00000440706.3 [Q96JA3-1]
B5MDU3
ENST00000396259.5
ENST00000622102.4
ENST00000396257.6 [Q96JA3-2]
A0A087X1S6
ENST00000258679.11 [Q96JA3-3]