Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 4 studies | 24% ± 6% |
Insufficient scRNA-seq data for expression of PLB1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 533.99 | 575 / 578 | 80% | 2.23 | 922 / 1155 |
uterus | 100% | 455.33 | 170 / 170 | 79% | 2.42 | 362 / 459 |
bladder | 100% | 404.62 | 21 / 21 | 77% | 3.27 | 389 / 504 |
prostate | 100% | 624.11 | 244 / 245 | 74% | 1.25 | 369 / 502 |
esophagus | 95% | 340.62 | 1368 / 1445 | 72% | 1.86 | 131 / 183 |
brain | 79% | 278.07 | 2075 / 2642 | 87% | 2.78 | 612 / 705 |
intestine | 94% | 1289.21 | 909 / 966 | 63% | 1.49 | 330 / 527 |
ovary | 83% | 244.10 | 149 / 180 | 74% | 1.95 | 317 / 430 |
breast | 92% | 272.16 | 422 / 459 | 58% | 1.36 | 653 / 1118 |
adrenal gland | 100% | 1237.12 | 258 / 258 | 46% | 1.73 | 105 / 230 |
thymus | 92% | 363.55 | 602 / 653 | 53% | 1.30 | 321 / 605 |
stomach | 62% | 146.32 | 222 / 359 | 73% | 1.95 | 210 / 286 |
skin | 74% | 574.60 | 1343 / 1809 | 60% | 2.26 | 283 / 472 |
kidney | 51% | 103.53 | 45 / 89 | 61% | 1.43 | 553 / 901 |
pancreas | 14% | 23.28 | 45 / 328 | 92% | 2.51 | 163 / 178 |
spleen | 100% | 1327.96 | 241 / 241 | 0% | 0 | 0 / 0 |
blood vessel | 98% | 477.37 | 1314 / 1335 | 0% | 0 | 0 / 0 |
adipose | 95% | 397.67 | 1144 / 1204 | 0% | 0 | 0 / 0 |
muscle | 85% | 307.70 | 681 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 81% | 3888.31 | 757 / 929 | 0% | 0 | 0 / 0 |
heart | 64% | 149.93 | 554 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 60% | 1.23 | 27 / 45 |
lymph node | 0% | 0 | 0 / 0 | 28% | 0.59 | 8 / 29 |
liver | 18% | 32.26 | 41 / 226 | 8% | 0.16 | 33 / 406 |
eye | 0% | 0 | 0 / 0 | 11% | 0.17 | 9 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0036151 | Biological process | phosphatidylcholine acyl-chain remodeling |
GO_2000344 | Biological process | positive regulation of acrosome reaction |
GO_0046340 | Biological process | diacylglycerol catabolic process |
GO_0019433 | Biological process | triglyceride catabolic process |
GO_0001523 | Biological process | retinoid metabolic process |
GO_0034638 | Biological process | phosphatidylcholine catabolic process |
GO_0046338 | Biological process | phosphatidylethanolamine catabolic process |
GO_0042572 | Biological process | retinol metabolic process |
GO_0006644 | Biological process | phospholipid metabolic process |
GO_0034478 | Biological process | phosphatidylglycerol catabolic process |
GO_0031526 | Cellular component | brush border membrane |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0004806 | Molecular function | triglyceride lipase activity |
GO_0004623 | Molecular function | phospholipase A2 activity |
GO_0047499 | Molecular function | calcium-independent phospholipase A2 activity |
GO_0004622 | Molecular function | lysophospholipase activity |
GO_0102545 | Molecular function | phosphatidyl phospholipase B activity |
GO_0050253 | Molecular function | retinyl-palmitate esterase activity |
Gene name | PLB1 |
Protein name | Phospholipase B1, membrane-associated (Phospholipase B) (hPLB) (Lysophospholipase) (EC 3.1.1.5) (Phospholipase A2) (EC 3.1.1.4) (Phospholipase B/lipase) (PLB/LIP) (Triacylglycerol lipase) (EC 3.1.1.3) Phospholipase B1 Phospholipase B1, membrane-associated (EC 3.1.1.3) (EC 3.1.1.4) (EC 3.1.1.5) (Lysophospholipase) (Phospholipase A2) (Phospholipase B/lipase) (Triacylglycerol lipase) |
Synonyms | PLB |
Description | FUNCTION: Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity). . |
Accessions | ENST00000422425.6 [Q6P1J6-3] ENST00000404858.5 H7C2A5 ENST00000411743.5 H7C012 Q6P1J6 H7BZW4 H7BYX7 ENST00000327757.10 [Q6P1J6-1] B2RWP8 H7C1D3 ENST00000416713.5 ENST00000444257.5 ENST00000436775.1 ENST00000436544.1 C9JYQ2 |