PLA2G4E report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PLA2G4E at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G4E at tissue level.

III. Associated gene sets

GO_0036149Biological processphosphatidylinositol acyl-chain remodeling
GO_0046475Biological processglycerophospholipid catabolic process
GO_2001137Biological processpositive regulation of endocytic recycling
GO_0070292Biological processN-acylphosphatidylethanolamine metabolic process
GO_0005886Cellular componentplasma membrane
GO_0031901Cellular componentearly endosome membrane
GO_0005829Cellular componentcytosol
GO_0005765Cellular componentlysosomal membrane
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0008970Molecular functionphospholipase A1 activity
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005544Molecular functioncalcium-dependent phospholipid binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0016410Molecular functionN-acyltransferase activity
GO_0005509Molecular functioncalcium ion binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene namePLA2G4E
Protein namePhospholipase A2 (EC 3.1.1.4)
Cytosolic phospholipase A2 epsilon (cPLA2-epsilon) (EC 3.1.1.4) (Calcium-dependent N-acyltransferase) (Phospholipase A2 group IVE)
Phospholipase A2 group IVE
phospholipase A2 (EC 3.1.1.4)
Synonyms
DescriptionFUNCTION: Calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain . Transfers the sn-1 fatty acyl chain of phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to generate N-acyl phosphatidylethanolamine (NAPE). Similarly can use plasmenylethanolamine as a fatty acyl acceptor to form N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt can serve as precursors of bioactive NAEs like N-arachidonoyl phosphatidylethanolamine also called anandamide . Has weak phospholipase A2 and lysophospholipase activities (By similarity). Regulates intracellular membrane trafficking that requires modulation of membrane curvature as it occurs by enrichment in lysophospholipids. Promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling (By similarity). .

AccessionsENST00000399518.3 [Q3MJ16-3]
A0A8Q3SIH7
A0A8Q3SIE9
ENST00000696117.1
A0A8Q3WM91
ENST00000696115.1
A0A8Q3SIA2
ENST00000696112.1
ENST00000696114.1
Q3MJ16
A0A8Q3SIG9
ENST00000696116.1
ENST00000696118.1