PLA2G15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G15 at tissue level.

III. Associated gene sets

GO_0006650Biological processglycerophospholipid metabolic process
GO_0006658Biological processphosphatidylserine metabolic process
GO_0006672Biological processceramide metabolic process
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0046338Biological processphosphatidylethanolamine catabolic process
GO_0009062Biological processfatty acid catabolic process
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0006651Biological processdiacylglycerol biosynthetic process
GO_0006644Biological processphospholipid metabolic process
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0008970Molecular functionphospholipase A1 activity
GO_0008374Molecular functionO-acyltransferase activity
GO_0052739Molecular functionphosphatidylserine 1-acylhydrolase activity
GO_0052740Molecular function1-acyl-2-lysophosphatidylserine acylhydrolase activity
GO_0005543Molecular functionphospholipid binding
GO_0047499Molecular functioncalcium-independent phospholipase A2 activity
GO_0016411Molecular functionacylglycerol O-acyltransferase activity
GO_0004622Molecular functionlysophospholipase activity
GO_0102545Molecular functionphosphatidyl phospholipase B activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene namePLA2G15
Protein namePhospholipase A2 group XV (1-O-acylceramide synthase) (ACS) (LCAT-like lysophospholipase) (LLPL) (EC 3.1.1.5) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (EC 2.3.1.-, EC 3.1.1.32, EC 3.1.1.4) (Lysosomal phospholipase A2) (LPLA2)
Phospholipase A2 group XV
Phospholipase A2 group XV (EC 3.1.1.32) (EC 3.1.1.4) (EC 3.1.1.5) (1-O-acylceramide synthase) (LCAT-like lysophospholipase) (Lysophospholipase 3) (Lysosomal phospholipase A and acyltransferase) (Lysosomal phospholipase A2)
SynonymsLYPLA3
UNQ341/PRO540
DescriptionFUNCTION: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments . Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) . Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines . Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide . Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress . Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines . .

AccessionsH3BMU8
ENST00000566188.5
ENST00000565744.5
H3BPT3
H3BM47
ENST00000564827.6
ENST00000444212.2
B4DPU0
H3BT70
ENST00000413021.2 [Q8NCC3-2]
ENST00000568082.1
Q8NCC3
B4DJW4
ENST00000219345.10 [Q8NCC3-1]
ENST00000566978.1