PLA1A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA1A at tissue level.

III. Associated gene sets

GO_0036150Biological processphosphatidylserine acyl-chain remodeling
GO_0006629Biological processlipid metabolic process
GO_0016042Biological processlipid catabolic process
GO_0006658Biological processphosphatidylserine metabolic process
GO_0005615Cellular componentextracellular space
GO_0002080Cellular componentacrosomal membrane
GO_0005576Cellular componentextracellular region
GO_0008970Molecular functionphospholipase A1 activity
GO_0052739Molecular functionphosphatidylserine 1-acylhydrolase activity

IV. Literature review

[source]
Gene namePLA1A
Protein namePhospholipase A1 member A (EC 3.1.1.111) (Phosphatidylserine-specific phospholipase A1) (PS-PLA1)
Phospholipase A1 member A (EC 3.1.1.111)
SynonymsNMD
PSPLA1
hCG_22568
DescriptionFUNCTION: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling . Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). .; FUNCTION: [Isoform 2]: Hydrolyzes lyso-PS but not PS. .

AccessionsENST00000494440.5
ENST00000475963.1
ENST00000273371.9 [Q53H76-1]
ENST00000488919.5 [Q53H76-4]
ENST00000495992.5 [Q53H76-3]
H7C4H1
Q53H76
G5E9W0