PJVK report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PJVK at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PJVK at tissue level.

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0050910Biological processdetection of mechanical stimulus involved in sensory perception of sound
GO_0097468Biological processprogrammed cell death in response to reactive oxygen species
GO_0000425Biological processpexophagy
GO_0120045Biological processstereocilium maintenance
GO_0000302Biological processresponse to reactive oxygen species
GO_1900063Biological processregulation of peroxisome organization
GO_0005778Cellular componentperoxisomal membrane
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0043025Cellular componentneuronal cell body
GO_0120044Cellular componentstereocilium base
GO_0035253Cellular componentciliary rootlet
GO_0005737Cellular componentcytoplasm

IV. Literature review

[source]
Gene namePJVK
Protein namePejvakin
DFNB59 protein (HCG2043344) (Pejvakin)
Pejvakin (Autosomal recessive deafness type 59 protein)
SynonymshCG_2043344
DFNB59
DescriptionFUNCTION: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. .

AccessionsENST00000644580.2
H7C3A9
Q0ZLH3
ENST00000642762.1
ENST00000643738.1
A0PK15
A0A2R8Y7D2
ENST00000642192.1
ENST00000642492.1
H7C1C3
ENST00000647226.1
ENST00000645572.1
ENST00000442710.5
ENST00000645817.1
ENST00000375129.8
A0A2R8YD96
A0A2R8Y564
ENST00000444615.1