PITRM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016485Biological processprotein processing
GO_0006626Biological processprotein targeting to mitochondrion
GO_0006508Biological processproteolysis
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004222Molecular functionmetalloendopeptidase activity
GO_0008047Molecular functionenzyme activator activity
GO_0008270Molecular functionzinc ion binding
GO_0008237Molecular functionmetallopeptidase activity

IV. Literature review

[source]
Gene namePITRM1
Protein namePresequence protease, mitochondrial
Pitrilysin metallopeptidase 1
Presequence protease, mitochondrial (hPreP) (EC 3.4.24.-) (Pitrilysin metalloproteinase 1) (Metalloprotease 1) (hMP1)
Presequence protease, mitochondrial (Pitrilysin metalloproteinase 1)
Pitrilysin metalloproteinase 1
SynonymsKIAA1104
MP1
PREP
DescriptionFUNCTION: Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing . Has an ATP-independent activity . Specifically cleaves peptides in the range of 5 to 65 residues . Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference . Degrades the transit peptides of mitochondrial proteins after their cleavage . Also degrades other unstructured peptides . It is also able to degrade amyloid-beta protein 40, one of the peptides produced by APP processing, when it accumulates in mitochondrion . It is a highly efficient protease, at least toward amyloid-beta protein 40 . Cleaves that peptide at a specific position and is probably not processive, releasing digested peptides intermediates that can be further cleaved subsequently . It is also able to degrade amyloid-beta protein 42 . .

AccessionsENST00000451454.5
ENST00000678601.1
A0A7I2V4N3
ENST00000678403.1
ENST00000678663.1
ENST00000678987.1
ENST00000678855.1
ENST00000677305.1
A0A7I2YQX5
ENST00000430362.2
A0A7I2V2T0
A0A7I2V5H2
ENST00000679210.1
ENST00000380994.6
ENST00000677001.1
ENST00000677384.1
B1APQ1
ENST00000678441.1
ENST00000424714.1
B1APQ0
H0Y7L7
ENST00000451104.6 [Q5JRX3-3]
ENST00000380989.6 [Q5JRX3-2]
ENST00000678811.1
ENST00000679134.1
H0Y4F7
ENST00000224949.9 [Q5JRX3-1]
ENST00000676953.1
A0A7I2V3L7
A0A7I2V449
A0A7I2V5K2
A0A7I2V4X7
A0A0A0MRX9
A0A7I2V3X0
Q5JRX3
ENST00000678972.1
A0A7I2V3B6
ENST00000677817.1
B4DEU0
A0A7I2V5R2
ENST00000677922.1
A0A7I2YQT2
ENST00000679309.1
ENST00000678436.1
A0A7I2V5C6
ENST00000455371.5
ENST00000678370.1
A0A7I2V397