PI4K2B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007032Biological processendosome organization
GO_0007030Biological processGolgi organization
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0005802Cellular componenttrans-Golgi network
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004430Molecular function1-phosphatidylinositol 4-kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePI4K2B
Protein namePhosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA)
Phosphatidylinositol 4-kinase type 2 (EC 2.7.1.67)
SynonymshCG_19614
DescriptionFUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell . This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments . The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) . Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. .

AccessionsQ8TCG2
ENST00000512921.4
G5E9Z4
ENST00000264864.8