PHLDA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0051898Biological processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0009653Biological processanatomical structure morphogenesis
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene namePHLDA3
Protein namePleckstrin homology-like domain family A member 3 (TDAG51/Ipl homolog 1)
SynonymsTIH1
DescriptionFUNCTION: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. .

AccessionsENST00000367311.5
ENST00000367309.1
Q9Y5J5