PHGDH report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0021782Biological processglial cell development
GO_0010468Biological processregulation of gene expression
GO_0070314Biological processG1 to G0 transition
GO_0021510Biological processspinal cord development
GO_0006544Biological processglycine metabolic process
GO_0031175Biological processneuron projection development
GO_0006566Biological processthreonine metabolic process
GO_0006541Biological processglutamine metabolic process
GO_0019530Biological processtaurine metabolic process
GO_0009448Biological processgamma-aminobutyric acid metabolic process
GO_0007420Biological processbrain development
GO_0006564Biological processL-serine biosynthetic process
GO_0021915Biological processneural tube development
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0004617Molecular functionphosphoglycerate dehydrogenase activity
GO_0009055Molecular functionelectron transfer activity
GO_0051287Molecular functionNAD binding
GO_0030060Molecular functionL-malate dehydrogenase (NAD+) activity

IV. Literature review

[source]
Gene namePHGDH
Protein nameD-3-phosphoglycerate dehydrogenase (EC 1.1.1.95)
Phosphoglycerate dehydrogenase
D-3-phosphoglycerate dehydrogenase (3-PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) (Malate dehydrogenase) (EC 1.1.1.37)
D-3-phosphoglycerate dehydrogenase
SynonymsPGDH3
DescriptionFUNCTION: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate. .

AccessionsA0A286YEZ0
ENST00000641513.1
A0A286YF22
Q8N5M8
ENST00000641891.1
A0A286YFC8
A0A286YER3
ENST00000641213.1
ENST00000641247.1
ENST00000641074.1
A0A286YFK5
ENST00000641720.1
ENST00000642041.1
A0A286YF34
A0A286YFL2
A0A286YFA2
A0A286YFM8
A0A286YF78
O43175
ENST00000641811.1
ENST00000641371.1
ENST00000641272.1
ENST00000641023.2
ENST00000641115.1
ENST00000641375.1
ENST00000641491.1
ENST00000369409.9
ENST00000641947.1
ENST00000641587.1
ENST00000641597.1
A0A286YFE1
A0A286YFF3
A0A2C9F2M7
A0A286YFB2
ENST00000641756.1
ENST00000641570.1
ENST00000493622.5