PFN4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PFN4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PFN4 at tissue level.

III. Associated gene sets

GO_0042989Biological processsequestering of actin monomers
GO_0120316Biological processsperm flagellum assembly
GO_1905198Biological processmanchette assembly
GO_0007283Biological processspermatogenesis
GO_0030317Biological processflagellated sperm motility
GO_0001675Biological processacrosome assembly
GO_0005938Cellular componentcell cortex
GO_0003785Molecular functionactin monomer binding
GO_0008289Molecular functionlipid binding

IV. Literature review

[source]
Gene namePFN4
Protein nameProfilin family member 4
Profilin-4 (Profilin IV)
Synonyms
DescriptionFUNCTION: Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis (By similarity). Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) . Contrary to other profilin family members, does not bind to actin in vitro . .

AccessionsQ8NHR9
ENST00000436622.1
A0A1D5RMN8
ENST00000313213.5