PERM1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PERM1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PERM1 at tissue level.

III. Associated gene sets

GO_0006355Biological processregulation of DNA-templated transcription
GO_0014850Biological processresponse to muscle activity
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus

IV. Literature review

[source]
Gene namePERM1
Protein namePGC-1 and ERR-induced regulator in muscle protein 1 (PPARGC1 and ESRR-induced regulator in muscle 1) (Peroxisome proliferator-activated receptor gamma coactivator 1 and estrogen-related receptor-induced regulator in muscle 1)
SynonymsC1orf170
DescriptionFUNCTION: Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4. .

AccessionsENST00000341290.6 [Q5SV97-3]
ENST00000694917.1 [Q5SV97-1]
Q5SV97
ENST00000433179.4 [Q5SV97-1]