PDZRN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007528Biological processneuromuscular junction development
GO_0031594Cellular componentneuromuscular junction
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene namePDZRN3
Protein namePDZ domain containing ring finger 3
Alternative protein PDZRN3
PDZ domain containing ring finger 3 (cDNA, FLJ79174, highly similar to PDZ domain-containing RING finger protein 3)
PDZ domain containing RING finger 3, isoform CRA_a (cDNA FLJ54738, highly similar to PDZ domain-containing RING finger protein 3)
E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)
SynonymsLNX3
hCG_15915
KIAA1095
SEMCAP3
DescriptionFUNCTION: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. .

AccessionsB7Z2I8
B2RWP2
ENST00000494559.5
ENST00000263666.9 [Q9UPQ7-1]
ENST00000308537.4 [Q9UPQ7-2]
B7ZAG0
E7ENB6
Q9UPQ7
C9JWE6
ENST00000466780.5
ENST00000462146.6
L8E852
ENST00000492909.1
H7C566
ENST00000479530.5