Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 16 studies | 48% ± 19% | |
fibroblast | 16 studies | 37% ± 16% | |
endothelial cell | 12 studies | 38% ± 16% | |
smooth muscle cell | 12 studies | 46% ± 17% | |
adipocyte | 10 studies | 61% ± 16% | |
glutamatergic neuron | 9 studies | 53% ± 24% | |
GABAergic neuron | 8 studies | 59% ± 23% | |
pericyte | 7 studies | 34% ± 6% | |
neuron | 6 studies | 36% ± 19% | |
cardiac muscle cell | 6 studies | 66% ± 20% | |
myofibroblast cell | 5 studies | 43% ± 26% | |
epithelial cell | 4 studies | 48% ± 26% | |
interneuron | 4 studies | 51% ± 14% | |
glial cell | 3 studies | 28% ± 2% | |
oligodendrocyte precursor cell | 3 studies | 28% ± 6% | |
glycinergic amacrine cell | 3 studies | 18% ± 2% | |
retinal pigment epithelial cell | 3 studies | 54% ± 17% | |
connective tissue cell | 3 studies | 48% ± 19% | |
goblet cell | 3 studies | 30% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 4715.49 | 244 / 245 | 100% | 47.24 | 502 / 502 |
breast | 100% | 3713.56 | 457 / 459 | 93% | 18.89 | 1041 / 1118 |
ovary | 100% | 8643.93 | 180 / 180 | 70% | 8.66 | 302 / 430 |
intestine | 97% | 7820.96 | 941 / 966 | 71% | 8.55 | 374 / 527 |
skin | 79% | 1882.07 | 1428 / 1809 | 85% | 19.24 | 401 / 472 |
esophagus | 99% | 6943.68 | 1426 / 1445 | 64% | 10.00 | 118 / 183 |
lung | 96% | 2307.76 | 552 / 578 | 58% | 6.56 | 674 / 1155 |
stomach | 83% | 4981.86 | 299 / 359 | 70% | 11.98 | 199 / 286 |
bladder | 100% | 7015.90 | 21 / 21 | 46% | 5.49 | 231 / 504 |
adrenal gland | 95% | 3740.46 | 244 / 258 | 51% | 9.62 | 117 / 230 |
uterus | 99% | 8938.73 | 169 / 170 | 45% | 14.60 | 206 / 459 |
brain | 38% | 623.40 | 994 / 2642 | 99% | 22.63 | 696 / 705 |
blood vessel | 100% | 7548.44 | 1330 / 1335 | 0% | 0 | 0 / 0 |
adipose | 99% | 3230.47 | 1192 / 1204 | 0% | 0 | 0 / 0 |
pancreas | 8% | 86.12 | 26 / 328 | 86% | 12.03 | 153 / 178 |
heart | 86% | 3359.08 | 739 / 861 | 0% | 0 | 0 / 0 |
kidney | 27% | 407.39 | 24 / 89 | 58% | 6.35 | 524 / 901 |
muscle | 79% | 2540.85 | 632 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 51% | 6.73 | 23 / 45 |
thymus | 17% | 236.23 | 111 / 653 | 17% | 2.13 | 104 / 605 |
eye | 0% | 0 | 0 / 0 | 13% | 0.87 | 10 / 80 |
lymph node | 0% | 0 | 0 / 0 | 10% | 0.60 | 3 / 29 |
liver | 0% | 0 | 0 / 226 | 5% | 0.61 | 21 / 406 |
spleen | 0% | 6.03 | 1 / 241 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0016567 | Biological process | protein ubiquitination |
GO_0007528 | Biological process | neuromuscular junction development |
GO_0031594 | Cellular component | neuromuscular junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0004842 | Molecular function | ubiquitin-protein transferase activity |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | PDZRN3 |
Protein name | PDZ domain containing ring finger 3 Alternative protein PDZRN3 PDZ domain containing ring finger 3 (cDNA, FLJ79174, highly similar to PDZ domain-containing RING finger protein 3) PDZ domain containing RING finger 3, isoform CRA_a (cDNA FLJ54738, highly similar to PDZ domain-containing RING finger protein 3) E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3) |
Synonyms | LNX3 hCG_15915 KIAA1095 SEMCAP3 |
Description | FUNCTION: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. . |
Accessions | B7Z2I8 B2RWP2 ENST00000494559.5 ENST00000263666.9 [Q9UPQ7-1] ENST00000308537.4 [Q9UPQ7-2] B7ZAG0 E7ENB6 Q9UPQ7 C9JWE6 ENST00000466780.5 ENST00000462146.6 L8E852 ENST00000492909.1 H7C566 ENST00000479530.5 |