PDP2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PDP2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDP2 at tissue level.

III. Associated gene sets

GO_0042093Biological processT-helper cell differentiation
GO_0006470Biological processprotein dephosphorylation
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004741Molecular function[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity
GO_0019909Molecular function[pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDP2
Protein namePyruvate dehydrogenase phosphatase catalytic subunit 2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial (PDP 2) (EC 3.1.3.43) (Pyruvate dehydrogenase phosphatase catalytic subunit 2) (PDPC 2)
SynonymsKIAA1348
DescriptionFUNCTION: Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (By similarity). .

AccessionsH3BV50
ENST00000311765.4
H3BSA5
H3BQX2
H3BTU5
ENST00000566776.1
ENST00000566543.1
H3BRB7
ENST00000568398.1
ENST00000561704.1
ENST00000568869.1
Q9P2J9