PDE6C | OmnibusX

Name	Number of supported studies	Average coverage
retinal cone cell	7 studies	39% ± 8%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDE6C at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	47.74	2522 / 2642	19%	0.27	136 / 705
kidney	93%	27.21	83 / 89	11%	0.16	99 / 901
thymus	100%	48.84	652 / 653	4%	0.06	26 / 605
esophagus	97%	34.70	1406 / 1445	6%	0.08	11 / 183
lung	99%	40.03	571 / 578	4%	0.08	51 / 1155
uterus	99%	65.96	169 / 170	4%	0.06	17 / 459
breast	99%	42.56	454 / 459	4%	0.08	46 / 1118
bladder	100%	50.57	21 / 21	3%	0.06	14 / 504
ovary	99%	59.11	179 / 180	2%	0.03	10 / 430
prostate	100%	55.05	245 / 245	1%	0.01	4 / 502
intestine	99%	37.93	954 / 966	2%	0.03	9 / 527
spleen	100%	46.68	241 / 241	0%	0	0 / 0
skin	97%	40.26	1749 / 1809	1%	0.01	5 / 472
stomach	95%	26.75	340 / 359	3%	0.06	8 / 286
blood vessel	97%	34.01	1300 / 1335	0%	0	0 / 0
adipose	96%	35.16	1157 / 1204	0%	0	0 / 0
adrenal gland	93%	24.09	241 / 258	1%	0.01	2 / 230
liver	89%	23.53	202 / 226	5%	0.09	19 / 406
muscle	94%	23.43	755 / 803	0%	0	0 / 0
pancreas	93%	20.76	304 / 328	1%	0.03	2 / 178
heart	89%	19.99	765 / 861	0%	0	0 / 0
peripheral blood	40%	6.38	373 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	2%	0.02	1 / 45
eye	0%	0	0 / 0	1%	0.09	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007601	Biological process	visual perception
GO_0046549	Biological process	retinal cone cell development
GO_0019933	Biological process	cAMP-mediated signaling
GO_0007603	Biological process	phototransduction, visible light
GO_0005886	Cellular component	plasma membrane
GO_0047555	Molecular function	3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115	Molecular function	3',5'-cyclic-AMP phosphodiesterase activity
GO_0046872	Molecular function	metal ion binding
GO_0030553	Molecular function	cGMP binding

Gene name	PDE6C
Protein name	Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' (EC 3.1.4.35) (cGMP phosphodiesterase 6C)
Synonyms	PDEA2
Description	FUNCTION: As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. .
Accessions	ENST00000371447.4 P51160

PDE6C report