Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 17 studies | 68% ± 23% | |
oligodendrocyte precursor cell | 12 studies | 40% ± 14% | |
endothelial cell | 10 studies | 30% ± 13% | |
glutamatergic neuron | 10 studies | 37% ± 18% | |
pericyte | 9 studies | 41% ± 21% | |
GABAergic neuron | 8 studies | 40% ± 22% | |
cardiac muscle cell | 6 studies | 66% ± 22% | |
ionocyte | 5 studies | 42% ± 14% | |
fibroblast | 5 studies | 37% ± 11% | |
retinal cone cell | 5 studies | 53% ± 23% | |
smooth muscle cell | 5 studies | 25% ± 10% | |
astrocyte | 4 studies | 39% ± 26% | |
glial cell | 4 studies | 32% ± 14% | |
microglial cell | 4 studies | 41% ± 22% | |
interneuron | 4 studies | 57% ± 28% | |
neuron | 3 studies | 30% ± 15% | |
retinal bipolar neuron | 3 studies | 28% ± 16% | |
Purkinje cell | 3 studies | 51% ± 32% | |
granule cell | 3 studies | 31% ± 9% | |
progenitor cell | 3 studies | 39% ± 21% | |
OFF-bipolar cell | 3 studies | 61% ± 23% | |
amacrine cell | 3 studies | 22% ± 5% | |
retinal pigment epithelial cell | 3 studies | 46% ± 30% | |
renal alpha-intercalated cell | 3 studies | 69% ± 33% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 99% | 2778.00 | 2610 / 2642 | 87% | 5.80 | 612 / 705 |
kidney | 93% | 1100.03 | 83 / 89 | 60% | 3.04 | 539 / 901 |
thymus | 64% | 372.35 | 420 / 653 | 67% | 2.24 | 403 / 605 |
lung | 99% | 1452.50 | 574 / 578 | 19% | 0.63 | 214 / 1155 |
stomach | 96% | 987.92 | 344 / 359 | 20% | 0.48 | 56 / 286 |
bladder | 95% | 2952.24 | 20 / 21 | 12% | 0.31 | 59 / 504 |
esophagus | 83% | 1405.18 | 1206 / 1445 | 20% | 0.36 | 37 / 183 |
intestine | 93% | 894.52 | 902 / 966 | 10% | 0.17 | 52 / 527 |
heart | 100% | 6443.03 | 858 / 861 | 0% | 0 | 0 / 0 |
breast | 73% | 771.29 | 337 / 459 | 26% | 0.85 | 287 / 1118 |
uterus | 76% | 1304.96 | 129 / 170 | 14% | 1.10 | 66 / 459 |
ovary | 85% | 1064.21 | 153 / 180 | 2% | 0.05 | 9 / 430 |
adipose | 82% | 685.59 | 993 / 1204 | 0% | 0 | 0 / 0 |
adrenal gland | 24% | 116.48 | 62 / 258 | 56% | 3.52 | 129 / 230 |
blood vessel | 76% | 1234.57 | 1008 / 1335 | 0% | 0 | 0 / 0 |
prostate | 59% | 571.53 | 145 / 245 | 9% | 0.15 | 43 / 502 |
pancreas | 17% | 80.46 | 55 / 328 | 25% | 0.42 | 44 / 178 |
skin | 6% | 31.98 | 112 / 1809 | 13% | 0.73 | 61 / 472 |
tonsil | 0% | 0 | 0 / 0 | 7% | 0.10 | 3 / 45 |
liver | 0% | 0 | 0 / 226 | 5% | 0.25 | 22 / 406 |
spleen | 4% | 16.10 | 10 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 2% | 18.86 | 20 / 929 | 0% | 0 | 0 / 0 |
muscle | 2% | 6.38 | 13 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 0.02 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0019933 | Biological process | cAMP-mediated signaling |
GO_0005764 | Cellular component | lysosome |
GO_0005829 | Cellular component | cytosol |
GO_0043025 | Cellular component | neuronal cell body |
GO_0047555 | Molecular function | 3',5'-cyclic-GMP phosphodiesterase activity |
GO_0004115 | Molecular function | 3',5'-cyclic-AMP phosphodiesterase activity |
GO_0004117 | Molecular function | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0048101 | Molecular function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | PDE1C |
Protein name | Uncharacterized protein PDE1C Phosphodiesterase (EC 3.1.4.-) Phosphodiesterase 1C Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3) |
Synonyms | |
Description | FUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a high affinity for both cAMP and cGMP . Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). . |
Accessions | A0A0A0MS69 ENST00000672256.1 ENST00000396193.5 Q8TAE4 ENST00000396189.2 A0A5F9ZGW6 ENST00000396182.6 [Q14123-2] Q75MP2 Q75MW3 Q14123 F8W905 ENST00000396184.7 [Q14123-2] ENST00000321453.12 [Q14123-1] ENST00000396191.6 [Q14123-1] |