PDE1C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019933Biological processcAMP-mediated signaling
GO_0005764Cellular componentlysosome
GO_0005829Cellular componentcytosol
GO_0043025Cellular componentneuronal cell body
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0004117Molecular functioncalmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO_0005516Molecular functioncalmodulin binding
GO_0048101Molecular functioncalmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene namePDE1C
Protein nameUncharacterized protein PDE1C
Phosphodiesterase (EC 3.1.4.-)
Phosphodiesterase 1C
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Cam-PDE 1C) (EC 3.1.4.17) (Hcam3)
Synonyms
DescriptionFUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes . Has a high affinity for both cAMP and cGMP . Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). .

AccessionsA0A0A0MS69
ENST00000672256.1
ENST00000396193.5
Q8TAE4
ENST00000396189.2
A0A5F9ZGW6
ENST00000396182.6 [Q14123-2]
Q75MP2
Q75MW3
Q14123
F8W905
ENST00000396184.7 [Q14123-2]
ENST00000321453.12 [Q14123-1]
ENST00000396191.6 [Q14123-1]