PARS2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PARS2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PARS2 at tissue level.

III. Associated gene sets

GO_0006433Biological processprolyl-tRNA aminoacylation
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004827Molecular functionproline-tRNA ligase activity
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePARS2
Protein nameProbable proline--tRNA ligase, mitochondrial (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) (Prolyl-tRNA synthetase 2, mitochondrial)
Synonyms
DescriptionFUNCTION: Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. The reaction occurs in a two steps: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). .

AccessionsENST00000371279.4
Q7L3T8