PANK4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PANK4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PANK4 at tissue level.

III. Associated gene sets

GO_0015939Biological processpantothenate metabolic process
GO_0015937Biological processcoenzyme A biosynthetic process
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0016791Molecular functionphosphatase activity
GO_0004594Molecular functionpantothenate kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePANK4
Protein namePantothenate kinase 4 putative variant (Pantothenate kinase 4, isoform CRA_b)
4'-phosphopantetheine phosphatase (Inactive pantothenic acid kinase 4)
4'-phosphopantetheine phosphatase (EC 3.1.3.-) (Inactive pantothenic acid kinase 4) (hPanK4)
4'-phosphopantetheine phosphatase (EC 3.1.3.-)
4'-phosphopantetheine phosphatase (Pantothenate kinase 4 (inactive))
SynonymshCG_24601
DescriptionFUNCTION: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway . Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms . Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein . May play a role in the physiological regulation of CoA intracellular levels (Probable). .

FUNCTION: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels. .

AccessionsH0Y9E4
ENST00000435556.8
ENST00000505228.5
ENST00000502512.1
ENST00000625442.1
ENST00000468002.2
ENST00000626423.2
D6RJF3
ENST00000628687.1
Q9NVE7
ENST00000378466.9
H0YA31
ENST00000486396.1
ENST00000630982.2
ENST00000615291.3
H0YA26
E9PHT6
ENST00000502770.2
ENST00000628406.1
ENST00000627774.1
H0YA02
Q7RTX2