I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 37% ± 18% | |
| GABAergic neuron | 3 studies | 34% ± 5% | |
| glutamatergic neuron | 3 studies | 34% ± 8% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| hepatocyte | 5 studies | 37% ± 18% | |
| GABAergic neuron | 3 studies | 34% ± 5% | |
| glutamatergic neuron | 3 studies | 34% ± 8% |
Insufficient scRNA-seq data for expression of PANK1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| liver | 99% | 3041.98 | 224 / 226 | 99% | 14.90 | 400 / 406 |
| stomach | 96% | 369.71 | 344 / 359 | 94% | 8.78 | 269 / 286 |
| thymus | 99% | 693.70 | 649 / 653 | 89% | 5.50 | 539 / 605 |
| kidney | 100% | 1248.21 | 89 / 89 | 87% | 8.12 | 787 / 901 |
| brain | 97% | 568.51 | 2553 / 2642 | 87% | 4.82 | 612 / 705 |
| intestine | 87% | 584.09 | 844 / 966 | 93% | 9.46 | 488 / 527 |
| ovary | 84% | 224.42 | 152 / 180 | 89% | 4.91 | 383 / 430 |
| bladder | 95% | 223.24 | 20 / 21 | 76% | 4.91 | 382 / 504 |
| uterus | 84% | 192.52 | 143 / 170 | 80% | 4.17 | 367 / 459 |
| adrenal gland | 96% | 486.25 | 247 / 258 | 65% | 2.69 | 149 / 230 |
| esophagus | 89% | 315.54 | 1292 / 1445 | 70% | 3.61 | 129 / 183 |
| skin | 100% | 990.99 | 1803 / 1809 | 57% | 2.26 | 268 / 472 |
| breast | 83% | 209.78 | 379 / 459 | 62% | 3.11 | 698 / 1118 |
| lung | 72% | 230.22 | 419 / 578 | 72% | 3.33 | 830 / 1155 |
| pancreas | 78% | 167.50 | 255 / 328 | 56% | 2.08 | 99 / 178 |
| prostate | 79% | 156.67 | 193 / 245 | 25% | 0.83 | 124 / 502 |
| ureter | 0% | 0 | 0 / 0 | 100% | 4.15 | 1 / 1 |
| muscle | 99% | 777.58 | 791 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 8.01 | 77 / 80 |
| heart | 88% | 501.12 | 759 / 861 | 0% | 0 | 0 / 0 |
| spleen | 88% | 203.88 | 212 / 241 | 0% | 0 | 0 / 0 |
| adipose | 85% | 219.37 | 1024 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 83% | 248.32 | 1114 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 60% | 2.49 | 27 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 1.62 | 14 / 29 |
| peripheral blood | 19% | 121.21 | 177 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0015937 | Biological process | coenzyme A biosynthetic process |
| GO_0005730 | Cellular component | nucleolus |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005829 | Cellular component | cytosol |
| GO_0030136 | Cellular component | clathrin-coated vesicle |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004594 | Molecular function | pantothenate kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_1905502 | Molecular function | acetyl-CoA binding |
| Gene name | PANK1 |
| Protein name | Pantothenate kinase 1 (hPanK) (hPanK1) (EC 2.7.1.33) (Pantothenic acid kinase 1) Pantothenate kinase 1 |
| Synonyms | PANK |
| Description | FUNCTION: [Isoform 1]: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. . |
| Accessions | ENST00000307534.10 ENST00000342512.4 [Q8TE04-2] A0A8C8KBT8 Q8TE04 ENST00000322191.10 [Q8TE04-3] |
