PAFAH2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PAFAH2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PAFAH2 at tissue level.

III. Associated gene sets

GO_0006629Biological processlipid metabolic process
GO_0007596Biological processblood coagulation
GO_0016042Biological processlipid catabolic process
GO_0005737Cellular componentcytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0047179Molecular functionplatelet-activating factor acetyltransferase activity
GO_0005543Molecular functionphospholipid binding

IV. Literature review

[source]
Gene namePAFAH2
Protein namePlatelet-activating factor acetylhydrolase 2, cytoplasmic (EC 3.1.1.47) (PAF:lysophospholipid transacetylase) (PAF:sphingosine transacetylase) (Platelet-activating factor acetyltransferase PAFAH2) (EC 2.3.1.149) (Serine-dependent phospholipase A2) (SD-PLA2) (hSD-PLA2)
1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47)
Synonyms
DescriptionFUNCTION: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation . Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). .

AccessionsENST00000439092.6
ENST00000374284.5
ENST00000374282.8
ENST00000441420.1
Q5SY01
Q5SY00
Q99487