OXCT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042182Biological processketone catabolic process
GO_0046952Biological processketone body catabolic process
GO_0046950Biological processcellular ketone body metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0008260Molecular functionsuccinyl-CoA:3-oxo-acid CoA-transferase activity

IV. Literature review

[source]
Gene nameOXCT1
Protein nameSuccinyl-CoA:3-ketoacid-coenzyme A transferase (EC 2.8.3.5)
3-oxoacid CoA-transferase 1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (SCOT) (EC 2.8.3.5) (3-oxoacid CoA-transferase 1) (Somatic-type succinyl-CoA:3-oxoacid CoA-transferase) (SCOT-s) (Succinyl-CoA:3-oxoacid CoA transferase)
Succinyl-CoA:3-ketoacid CoA transferase
SynonymshCG_37537
SCOT
OXCT
DescriptionFUNCTION: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production . Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). .

FUNCTION: Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. .

AccessionsENST00000509987.1
E9PDW2
A1E286
ENST00000510634.5 [P55809-2]
ENST00000196371.10 [P55809-1]
ENST00000512084.5 [P55809-2]
P55809
A0A024R040