OTOF | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of OTOF at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	98%	136.64	252 / 258	15%	0.43	34 / 230
brain	95%	1189.74	2523 / 2642	16%	0.37	111 / 705
intestine	86%	65.32	827 / 966	5%	0.13	28 / 527
breast	77%	63.63	353 / 459	7%	0.16	83 / 1118
spleen	80%	74.39	194 / 241	0%	0	0 / 0
muscle	72%	95.42	580 / 803	0%	0	0 / 0
skin	65%	45.96	1179 / 1809	6%	0.12	29 / 472
stomach	61%	40.54	219 / 359	7%	0.20	20 / 286
adipose	67%	48.66	806 / 1204	0%	0	0 / 0
bladder	48%	21.67	10 / 21	19%	0.89	97 / 504
lung	55%	38.41	317 / 578	7%	0.27	85 / 1155
esophagus	53%	40.84	770 / 1445	7%	0.35	12 / 183
thymus	48%	24.95	316 / 653	1%	0.02	7 / 605
peripheral blood	45%	83.40	417 / 929	0%	0	0 / 0
prostate	40%	20.13	97 / 245	0%	0.00	1 / 502
ovary	27%	15.02	48 / 180	11%	0.33	46 / 430
uterus	24%	11.35	41 / 170	10%	0.41	47 / 459
pancreas	24%	13.46	79 / 328	4%	0.14	7 / 178
lymph node	0%	0	0 / 0	24%	3.21	7 / 29
heart	18%	7.57	152 / 861	0%	0	0 / 0
blood vessel	15%	8.13	199 / 1335	0%	0	0 / 0
kidney	10%	6.40	9 / 89	1%	0.02	7 / 901
liver	4%	3.41	10 / 226	2%	0.06	10 / 406
tonsil	0%	0	0 / 0	7%	0.11	3 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0061025	Biological process	membrane fusion
GO_0007605	Biological process	sensory perception of sound
GO_0016079	Biological process	synaptic vesicle exocytosis
GO_0046928	Biological process	regulation of neurotransmitter secretion
GO_0016323	Cellular component	basolateral plasma membrane
GO_0042995	Cellular component	cell projection
GO_0000139	Cellular component	Golgi membrane
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0005829	Cellular component	cytosol
GO_0042734	Cellular component	presynaptic membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005509	Molecular function	calcium ion binding
GO_0003674	Molecular function	molecular_function

Gene name	OTOF
Protein name	Otoferlin (Fer-1-like protein 2) Otoferlin
Synonyms	FER1L2
Description	FUNCTION: Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity). .
Accessions	ENST00000339598.8 [Q9HC10-2] Q9HC10 ENST00000338581.10 [Q9HC10-4] ENST00000402415.8 ENST00000426958.1 A0A2U3TZT7 H7BZJ5 ENST00000272371.7 [Q9HC10-1] ENST00000403946.7 [Q9HC10-5]

OTOF report