I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 20% ± 2% | |
| interneuron | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| glutamatergic neuron | 4 studies | 20% ± 2% | |
| interneuron | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 3 studies | 22% ± 1% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 608.08 | 180 / 180 | 100% | 10.14 | 430 / 430 |
| brain | 100% | 424.91 | 2638 / 2642 | 100% | 12.12 | 704 / 705 |
| breast | 100% | 378.95 | 458 / 459 | 100% | 9.07 | 1114 / 1118 |
| thymus | 100% | 444.98 | 653 / 653 | 99% | 7.70 | 600 / 605 |
| prostate | 100% | 415.88 | 245 / 245 | 99% | 6.86 | 497 / 502 |
| adrenal gland | 100% | 780.01 | 257 / 258 | 99% | 8.70 | 228 / 230 |
| uterus | 100% | 553.89 | 170 / 170 | 98% | 6.94 | 448 / 459 |
| kidney | 100% | 355.34 | 89 / 89 | 98% | 7.65 | 879 / 901 |
| esophagus | 100% | 314.28 | 1439 / 1445 | 98% | 5.28 | 179 / 183 |
| skin | 100% | 381.18 | 1804 / 1809 | 97% | 8.98 | 460 / 472 |
| bladder | 100% | 388.43 | 21 / 21 | 96% | 5.30 | 486 / 504 |
| pancreas | 98% | 208.95 | 322 / 328 | 98% | 4.62 | 174 / 178 |
| liver | 98% | 270.79 | 222 / 226 | 98% | 5.37 | 396 / 406 |
| intestine | 100% | 392.84 | 964 / 966 | 96% | 4.70 | 504 / 527 |
| lung | 96% | 305.66 | 554 / 578 | 99% | 7.23 | 1148 / 1155 |
| stomach | 99% | 289.77 | 354 / 359 | 94% | 4.82 | 270 / 286 |
| spleen | 100% | 559.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 6.25 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.38 | 1 / 1 |
| blood vessel | 100% | 321.63 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 342.65 | 1197 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 351.32 | 796 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 354.78 | 837 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 5.89 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 96% | 7.28 | 77 / 80 |
| peripheral blood | 57% | 200.27 | 529 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002949 | Biological process | tRNA threonylcarbamoyladenosine modification |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0061711 | Molecular function | N(6)-L-threonylcarbamoyladenine synthase activity |
| Gene name | OSGEPL1 |
| Protein name | N(6)-L-threonylcarbamoyladenine synthase (EC 2.3.1.234) tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase-like protein 1) (OSGEP-like protein 1) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEPL1) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1) |
| Synonyms | GCP1 |
| Description | FUNCTION: Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. . |
| Accessions | ENST00000520350.1 ENST00000517895.5 ENST00000264151.10 [Q9H4B0-1] E5RIL9 E7EVL7 Q9H4B0 E5RGZ1 ENST00000519810.5 [Q9H4B0-2] ENST00000521630.1 ENST00000522700.5 [Q9H4B0-1] |
