OPRPN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OPRPN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OPRPN at tissue level.

III. Associated gene sets

GO_0051930Biological processregulation of sensory perception of pain
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0030414Molecular functionpeptidase inhibitor activity

IV. Literature review

[source]
Gene nameOPRPN
Protein nameOpiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin]
SynonymsBPLP
PROL1
DescriptionFUNCTION: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. .

AccessionsQ99935
ENST00000399575.7