OMA1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OMA1 at tissue level.

III. Associated gene sets

GO_0097009Biological processenergy homeostasis
GO_0034982Biological processmitochondrial protein processing
GO_0002024Biological processdiet induced thermogenesis
GO_0016540Biological processprotein autoprocessing
GO_0140468Biological processHRI-mediated signaling
GO_0033108Biological processmitochondrial respiratory chain complex assembly
GO_1903850Biological processregulation of cristae formation
GO_0031638Biological processzymogen activation
GO_0042407Biological processcristae formation
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0010637Biological processnegative regulation of mitochondrial fusion
GO_0006629Biological processlipid metabolic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_0006006Biological processglucose metabolic process
GO_0140467Biological processintegrated stress response signaling
GO_0006515Biological processprotein quality control for misfolded or incompletely synthesized proteins
GO_0031966Cellular componentmitochondrial membrane
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005743Cellular componentmitochondrial inner membrane
GO_0008289Molecular functionlipid binding
GO_0046872Molecular functionmetal ion binding
GO_0004222Molecular functionmetalloendopeptidase activity

IV. Literature review

[source]
Gene nameOMA1
Protein nameMetalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)
Metalloendopeptidase OMA1, mitochondrial (Overlapping with the m-AAA protease 1 homolog)
OMA1 zinc metallopeptidase
SynonymsMPRP1
DescriptionFUNCTION: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria . Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1 . Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion . Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae . In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome . May also cleave UQCC3 in response to mitochondrial depolarization . Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR . Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (By similarity). Binds cardiolipin, possibly regulating its protein turnover (By similarity). Required for the stability of the respiratory supercomplexes (By similarity). .

AccessionsX6RDQ1
ENST00000419242.5
Q96E52
ENST00000456980.5
X6RD49
ENST00000453710.1
ENST00000426139.5
X6RL62
X6RIG5
ENST00000421528.6
ENST00000371226.8 [Q96E52-1]
ENST00000482274.2
H7BZX2
S4R3A3