OC90 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of OC90 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OC90 at tissue level.

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0045299Biological processotolith mineralization
GO_0008150Biological processbiological_process
GO_0016042Biological processlipid catabolic process
GO_0050482Biological processarachidonic acid secretion
GO_0005575Cellular componentcellular_component
GO_0005576Cellular componentextracellular region
GO_0031012Cellular componentextracellular matrix
GO_0005509Molecular functioncalcium ion binding
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005198Molecular functionstructural molecule activity
GO_0005543Molecular functionphospholipid binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameOC90
Protein nameOtoconin-90 (Oc90) (Phospholipase A2 homolog)
SynonymsPLA2L
DescriptionFUNCTION: Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity. .

AccessionsQ02509
ENST00000254627.4 [Q02509-1]