NUDT8 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NUDT8 at tissue level.

III. Associated gene sets

GO_0036114Biological processmedium-chain fatty-acyl-CoA catabolic process
GO_0044580Biological processbutyryl-CoA catabolic process
GO_2001294Biological processmalonyl-CoA catabolic process
GO_1901289Biological processsuccinyl-CoA catabolic process
GO_0015938Biological processcoenzyme A catabolic process
GO_0046356Biological processacetyl-CoA catabolic process
GO_1902859Biological processpropionyl-CoA catabolic process
GO_0005739Cellular componentmitochondrion
GO_0030145Molecular functionmanganese ion binding
GO_0010945Molecular functioncoenzyme A diphosphatase activity
GO_0000287Molecular functionmagnesium ion binding

IV. Literature review

[source]
Gene nameNUDT8
Protein nameMitochondrial coenzyme A diphosphatase NUDT8 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 8) (Nudix motif 8)
Synonyms
DescriptionFUNCTION: Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). .

AccessionsENST00000376693.3 [Q8WV74-1]
Q8WV74
ENST00000301490.8 [Q8WV74-2]