I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| platelet | 4 studies | 31% ± 4% | |
| GABAergic neuron | 3 studies | 24% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| platelet | 4 studies | 31% ± 4% | |
| GABAergic neuron | 3 studies | 24% ± 6% |
Insufficient scRNA-seq data for expression of NT5M at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 677.61 | 2640 / 2642 | 100% | 20.91 | 703 / 705 |
| prostate | 100% | 283.94 | 244 / 245 | 99% | 10.84 | 496 / 502 |
| ovary | 99% | 276.53 | 179 / 180 | 93% | 8.70 | 398 / 430 |
| kidney | 99% | 272.17 | 88 / 89 | 87% | 10.29 | 782 / 901 |
| breast | 93% | 144.10 | 426 / 459 | 89% | 9.40 | 992 / 1118 |
| uterus | 99% | 315.01 | 169 / 170 | 78% | 12.14 | 358 / 459 |
| skin | 80% | 110.57 | 1455 / 1809 | 95% | 13.98 | 447 / 472 |
| thymus | 86% | 125.89 | 561 / 653 | 63% | 5.37 | 381 / 605 |
| lung | 82% | 117.25 | 476 / 578 | 59% | 4.60 | 682 / 1155 |
| adrenal gland | 50% | 57.90 | 129 / 258 | 87% | 11.02 | 199 / 230 |
| esophagus | 92% | 262.32 | 1332 / 1445 | 42% | 2.84 | 76 / 183 |
| bladder | 86% | 264.86 | 18 / 21 | 39% | 3.39 | 199 / 504 |
| intestine | 88% | 238.91 | 851 / 966 | 35% | 1.90 | 185 / 527 |
| stomach | 78% | 125.20 | 279 / 359 | 35% | 1.87 | 100 / 286 |
| pancreas | 69% | 82.70 | 225 / 328 | 39% | 2.23 | 69 / 178 |
| eye | 0% | 0 | 0 / 0 | 100% | 20.72 | 80 / 80 |
| muscle | 100% | 501.72 | 803 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 438.77 | 921 / 929 | 0% | 0 | 0 / 0 |
| heart | 98% | 351.36 | 844 / 861 | 0% | 0 | 0 / 0 |
| spleen | 96% | 162.20 | 231 / 241 | 0% | 0 | 0 / 0 |
| adipose | 92% | 147.71 | 1103 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 10.44 | 40 / 45 |
| liver | 35% | 39.72 | 80 / 226 | 53% | 3.92 | 216 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 76% | 4.89 | 22 / 29 |
| blood vessel | 50% | 58.50 | 661 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046079 | Biological process | dUMP catabolic process |
| GO_0009223 | Biological process | pyrimidine deoxyribonucleotide catabolic process |
| GO_0006260 | Biological process | DNA replication |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0008252 | Molecular function | nucleotidase activity |
| GO_0008253 | Molecular function | 5'-nucleotidase activity |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0000166 | Molecular function | nucleotide binding |
| Gene name | NT5M |
| Protein name | 5',3'-nucleotidase, mitochondrial (Mitochondrial 5' nucleotidase) 5',3'-nucleotidase, mitochondrial 5'(3')-deoxyribonucleotidase, mitochondrial (5',3'-nucleotidase, mitochondrial) (EC 3.1.3.-) (Deoxy-5'-nucleotidase 2) (dNT-2) |
| Synonyms | DNT2 |
| Description | FUNCTION: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. . |
| Accessions | ENST00000483704.5 Q9NPB1 ENST00000616989.1 ENST00000478373.6 J3QRN4 J3QLR5 ENST00000470418.5 ENST00000389022.9 Q2I378 K7EPW8 |
