NSUN3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002127Biological processtRNA wobble base cytosine methylation
GO_0070129Biological processregulation of mitochondrial translation
GO_0031167Biological processrRNA methylation
GO_0005762Cellular componentmitochondrial large ribosomal subunit
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0000049Molecular functiontRNA binding
GO_0016428Molecular functiontRNA (cytidine-5-)-methyltransferase activity
GO_0008168Molecular functionmethyltransferase activity

IV. Literature review

[source]
Gene nameNSUN3
Protein nametRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 3)
NOP2/Sun RNA methyltransferase 3
SynonymsMSTP077
UG0651E06
DescriptionFUNCTION: Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met) . mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5-formylcytosine (f(5)c) at this position . mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation . .

AccessionsENST00000483378.1
ENST00000314622.9
Q9H649
F8WF52