NEK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0006468Biological processprotein phosphorylation
GO_0051301Biological processcell division
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0000278Biological processmitotic cell cycle
GO_2000772Biological processregulation of cellular senescence
GO_0097014Cellular componentciliary plasm
GO_0005829Cellular componentcytosol
GO_0036064Cellular componentciliary basal body
GO_0035869Cellular componentciliary transition zone
GO_0035253Cellular componentciliary rootlet
GO_0005737Cellular componentcytoplasm
GO_0030145Molecular functionmanganese ion binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameNEK4
Protein nameSerine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
non-specific serine/threonine protein kinase (EC 2.7.11.1)
NIMA related kinase 4
SynonymsSTK2
DescriptionFUNCTION: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. .

AccessionsENST00000487068.1
ENST00000496822.1
H7C5M0
ENST00000383721.8 [P51957-2]
F8WAX1
ENST00000461689.5
ENST00000233027.10 [P51957-1]
E7EX48
Q05DF6
A0A059V7J1
ENST00000535191.5 [P51957-3]
P51957