I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 34% ± 10% | |
| glutamatergic neuron | 3 studies | 28% ± 10% | |
| interneuron | 3 studies | 39% ± 22% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 34% ± 10% | |
| glutamatergic neuron | 3 studies | 28% ± 10% | |
| interneuron | 3 studies | 39% ± 22% |
Insufficient scRNA-seq data for expression of NDST4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 91% | 36.73 | 223 / 245 | 9% | 0.18 | 46 / 502 |
| spleen | 82% | 26.73 | 198 / 241 | 0% | 0 | 0 / 0 |
| ovary | 79% | 43.59 | 143 / 180 | 0% | 0 | 0 / 430 |
| brain | 43% | 7.22 | 1131 / 2642 | 32% | 1.21 | 227 / 705 |
| stomach | 62% | 7.99 | 221 / 359 | 3% | 0.12 | 8 / 286 |
| uterus | 59% | 19.21 | 100 / 170 | 4% | 0.11 | 20 / 459 |
| bladder | 48% | 5.33 | 10 / 21 | 3% | 0.29 | 13 / 504 |
| intestine | 42% | 3.98 | 401 / 966 | 1% | 0.02 | 4 / 527 |
| blood vessel | 24% | 2.79 | 316 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 1.29 | 4 / 29 |
| skin | 12% | 1.12 | 210 / 1809 | 1% | 0.06 | 7 / 472 |
| lung | 10% | 0.63 | 56 / 578 | 3% | 0.14 | 34 / 1155 |
| breast | 4% | 0.27 | 19 / 459 | 7% | 1.52 | 81 / 1118 |
| adipose | 10% | 0.98 | 122 / 1204 | 0% | 0 | 0 / 0 |
| esophagus | 7% | 0.62 | 102 / 1445 | 2% | 0.05 | 3 / 183 |
| heart | 7% | 0.48 | 59 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 2% | 0.10 | 4 / 258 | 4% | 0.24 | 9 / 230 |
| thymus | 4% | 0.27 | 27 / 653 | 1% | 0.03 | 5 / 605 |
| pancreas | 3% | 0.14 | 9 / 328 | 2% | 0.08 | 3 / 178 |
| muscle | 4% | 0.19 | 29 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 2% | 0.10 | 15 / 929 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 1% | 0.04 | 6 / 406 |
| kidney | 1% | 0.08 | 1 / 89 | 0% | 0.01 | 2 / 901 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015014 | Biological process | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process |
| GO_0030210 | Biological process | heparin biosynthetic process |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0015016 | Molecular function | [heparan sulfate]-glucosamine N-sulfotransferase activity |
| GO_0019213 | Molecular function | deacetylase activity |
| GO_0050119 | Molecular function | N-acetylglucosamine deacetylase activity |
| Gene name | NDST4 |
| Protein name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (EC 2.8.2.8) (Glucosaminyl N-deacetylase/N-sulfotransferase 4) (NDST-4) (N-heparan sulfate sulfotransferase 4) (N-HSST 4) [Includes: Heparan sulfate N-deacetylase 4 (EC 3.-.-.-); Heparan sulfate N-sulfotransferase 4 (EC 2.8.2.-)] |
| Synonyms | HSST4 |
| Description | FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). . |
| Accessions | ENST00000613194.4 [Q9H3R1-2] ENST00000264363.7 [Q9H3R1-1] Q9H3R1 ENST00000504854.1 [Q9H3R1-2] |
