NCEH1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006805Biological processxenobiotic metabolic process
GO_0034383Biological processlow-density lipoprotein particle clearance
GO_0046485Biological processether lipid metabolic process
GO_0016042Biological processlipid catabolic process
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0004771Molecular functionsterol esterase activity
GO_0017171Molecular functionserine hydrolase activity
GO_0042301Molecular functionphosphate ion binding
GO_0047378Molecular functionacetylalkylglycerol acetylhydrolase activity

IV. Literature review

[source]
Gene nameNCEH1
Protein nameNeutral cholesterol ester hydrolase 1 (EC 3.1.1.71) (Acetylalkylglycerol acetylhydrolase) (Arylacetamide deacetylase-like 1)
Neutral cholesterol ester hydrolase 1
Neutral cholesterol ester hydrolase 1 (NCEH) (EC 3.1.1.-) (Acetylalkylglycerol acetylhydrolase) (2-acetyl MAGE hydrolase) (EC 3.1.1.71) (Arylacetamide deacetylase-like 1)
SynonymsAADACL1
KIAA1363
DescriptionFUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor . May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration . .

AccessionsENST00000424772.2
ENST00000543711.5 [Q6PIU2-3]
ENST00000421723.2
Q6PIU2
ENST00000475381.7 [Q6PIU2-1]
A0A0A0MTJ9
ENST00000538775.5
F8WE33
H7C046