NAGS report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NAGS at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NAGS at tissue level.

III. Associated gene sets

GO_0006536Biological processglutamate metabolic process
GO_0000050Biological processurea cycle
GO_0006526Biological processarginine biosynthetic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004042Molecular functionacetyl-CoA:L-glutamate N-acetyltransferase activity
GO_0103045Molecular functionmethione N-acyltransferase activity

IV. Literature review

[source]
Gene nameNAGS
Protein nameN-acetylglutamate synthase
N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) (Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]
NAGS protein (cDNA FLJ54171, highly similar to N-acetylglutamate synthase, mitochondrial)
Synonyms
DescriptionFUNCTION: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. .

AccessionsK7EK11
ENST00000589767.1
ENST00000293404.8
Q8N159
Q2NKP2