NAA80 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NAA80 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NAA80 at tissue level.

III. Associated gene sets

GO_0017190Biological processN-terminal peptidyl-aspartic acid acetylation
GO_0006473Biological processprotein acetylation
GO_0030047Biological processactin modification
GO_0018002Biological processN-terminal peptidyl-glutamic acid acetylation
GO_0008064Biological processregulation of actin polymerization or depolymerization
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1905502Molecular functionacetyl-CoA binding
GO_0008080Molecular functionN-acetyltransferase activity
GO_0004596Molecular functionpeptide alpha-N-acetyltransferase activity

IV. Literature review

[source]
Gene nameNAA80
Protein nameN-alpha-acetyltransferase 80 (HsNAAA80) (EC 2.3.1.-) (N-acetyltransferase 6) (Protein fusion-2) (Protein fus-2)
N-alpha-acetyltransferase 80, NatH catalytic subunit
SynonymsFUS2
NAT6
DescriptionFUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) . N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation . In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu . In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp . May act as a tumor suppressor . .

AccessionsC9JL88
ENST00000443094.3 [Q93015-1]
Q93015
ENST00000442620.5
ENST00000450489.1
C9J451
A0A1D5RMQ1
ENST00000417393.1 [Q93015-1]
ENST00000443842.1 [Q93015-1]
ENST00000354862.4 [Q93015-2]
ENST00000452674.1