MTRF1 | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	21% ± 7%	Explore
glutamatergic neuron	3 studies	27% ± 7%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	676.19	1445 / 1445	100%	9.37	183 / 183
intestine	100%	794.26	966 / 966	99%	10.16	524 / 527
stomach	100%	770.74	359 / 359	99%	9.81	284 / 286
brain	99%	456.98	2622 / 2642	100%	6.79	703 / 705
pancreas	100%	781.65	328 / 328	99%	7.48	176 / 178
bladder	100%	665.62	21 / 21	99%	8.46	498 / 504
uterus	100%	525.33	170 / 170	99%	7.69	453 / 459
lung	99%	546.27	570 / 578	100%	7.03	1152 / 1155
prostate	100%	813.15	245 / 245	98%	5.23	492 / 502
breast	100%	556.16	459 / 459	98%	6.00	1095 / 1118
thymus	100%	759.57	653 / 653	98%	5.63	590 / 605
kidney	100%	614.85	89 / 89	96%	6.69	867 / 901
ovary	100%	590.89	180 / 180	96%	5.65	412 / 430
adrenal gland	100%	967.01	258 / 258	93%	4.66	214 / 230
liver	100%	548.47	226 / 226	91%	4.85	369 / 406
skin	100%	606.07	1807 / 1809	89%	6.99	421 / 472
muscle	100%	671.53	803 / 803	0%	0	0 / 0
spleen	100%	1222.26	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.06	1 / 1
adipose	100%	500.40	1202 / 1204	0%	0	0 / 0
blood vessel	99%	352.94	1321 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	5.29	44 / 45
lymph node	0%	0	0 / 0	97%	9.55	28 / 29
heart	96%	441.49	828 / 861	0%	0	0 / 0
peripheral blood	81%	475.31	751 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	64%	3.70	51 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

Gene name	MTRF1
Protein name	MTRF1 protein (Mitochondrial translation release factor 1) (Mitochondrial translational release factor 1, isoform CRA_b) Mitochondrial translation release factor 1 Peptide chain release factor 1, mitochondrial (MRF-1) (MtRF-1)
Synonyms	hCG_32761
Description	FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA . Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively . Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA . .
Accessions	ENST00000379477.5 [O75570-1] Q8N6Z2 A0A087WZ41 A0A087X1S1 ENST00000497679.6 ENST00000430347.3 X6RFD4 ENST00000452359.5 ENST00000379480.9 [O75570-1] ENST00000480434.5 O75570 ENST00000239852.10

GO_0070126	Biological process	mitochondrial translational termination
GO_0005739	Cellular component	mitochondrion
GO_0003747	Molecular function	translation release factor activity
GO_0016149	Molecular function	translation release factor activity, codon specific

MTRF1 report